Increased mammary blood flow in the lactating goat induced by parathyroid hormone-related protein - PubMed (original) (raw)
Comparative Study
Increased mammary blood flow in the lactating goat induced by parathyroid hormone-related protein
C G Prosser et al. Exp Physiol. 1994 Jul.
Free article
Abstract
Human synthetic parathyroid hormone-related protein (PTHrP) increased mammary blood flow (MBF) following close-arterial infusion via the external pudic artery in goats during mid-lactation. MBF increased 74 +/- 8% within 30 min of the start of continuous infusion of PTHrP compared with 10 +/- 3% in controls. MBF decreased by 90 min, however, and was not different from control values for the remainder of the infusion. The increase in plasma concentrations of calcium and decrease in phosphate during PTHrP suggests that this was not due to altered activity of PTHrP, but may relate to downregulation of response or production of counter-regulatory vasoconstrictive agents within the gland. This problem was alleviated when PTHrP was infused in a pulsatile fashion. An average 14-40% increase in MBF was achieved over 6 h, but this did not alter the rate of milk secretion, suggesting that mammary hyperaemia is not sufficient by itself to increase milk yield in the normally lactating goat. MBF increased in a dose-dependent fashion, although the lowest dose used to give a detectable response was approximately 40-fold higher than the concentration normally present in the mammary venous circulation. Thus, endogenous PTHrP may not be an important regulator of MBF during lactation in the goat.
Similar articles
- Increase in milk secretion and mammary blood flow by intra-arterial infusion of insulin-like growth factor-I into the mammary gland of the goat.
Prosser CG, Fleet IR, Corps AN, Froesch ER, Heap RB. Prosser CG, et al. J Endocrinol. 1990 Sep;126(3):437-43. doi: 10.1677/joe.0.1260437. J Endocrinol. 1990. PMID: 2212935 - Production of parathyroid hormone-related protein by the mammary gland of the goat.
Ratcliffe WA, Thompson GE, Care AD, Peaker M. Ratcliffe WA, et al. J Endocrinol. 1992 Apr;133(1):87-93. doi: 10.1677/joe.0.1330087. J Endocrinol. 1992. PMID: 1517711 - Mammary blood flow does not limit milk yield in lactating goats.
Lacasse P, Prosser CG. Lacasse P, et al. J Dairy Sci. 2003 Jun;86(6):2094-7. doi: 10.3168/jds.S0022-0302(03)73798-9. J Dairy Sci. 2003. PMID: 12836945 - Parathyroid hormone-related protein: a regulated calcium-mobilizing product of the mammary gland.
Thiede MA. Thiede MA. J Dairy Sci. 1994 Jul;77(7):1952-63. doi: 10.3168/jds.S0022-0302(94)77141-1. J Dairy Sci. 1994. PMID: 7929957 Review. - TRIENNIAL LACTATION SYMPOSIUM/BOLFA: Serotonin and the regulation of calcium transport in dairy cows.
Hernandez LL. Hernandez LL. J Anim Sci. 2017 Dec;95(12):5711-5719. doi: 10.2527/jas2017.1673. J Anim Sci. 2017. PMID: 29293773 Free PMC article. Review.
Cited by
- Mechanisms of vasodilation to PTH 1-84, PTH 1-34, and PTHrP 1-34 in rat bone resistance arteries.
Benson T, Menezes T, Campbell J, Bice A, Hood B, Prisby R. Benson T, et al. Osteoporos Int. 2016 May;27(5):1817-26. doi: 10.1007/s00198-015-3460-z. Epub 2016 Jan 5. Osteoporos Int. 2016. PMID: 26733378 - Biology of glucose transport in the mammary gland.
Zhao FQ. Zhao FQ. J Mammary Gland Biol Neoplasia. 2014 Mar;19(1):3-17. doi: 10.1007/s10911-013-9310-8. Epub 2013 Nov 13. J Mammary Gland Biol Neoplasia. 2014. PMID: 24221747 Review. - Triennial Lactation Symposium: A local affair: How the mammary gland adapts to changes in milking frequency.
Wall EH, McFadden TB. Wall EH, et al. J Anim Sci. 2012 May;90(5):1695-707. doi: 10.2527/jas.2011-4790. Epub 2011 Dec 28. J Anim Sci. 2012. PMID: 22205668 Free PMC article. Review. - Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation.
VanHouten JN, Dann P, Stewart AF, Watson CJ, Pollak M, Karaplis AC, Wysolmerski JJ. VanHouten JN, et al. J Clin Invest. 2003 Nov;112(9):1429-36. doi: 10.1172/JCI19504. J Clin Invest. 2003. PMID: 14597768 Free PMC article. - Parathyroid hormone-related protein and its receptors: nuclear functions and roles in the renal and cardiovascular systems, the placental trophoblasts and the pancreatic islets.
Clemens TL, Cormier S, Eichinger A, Endlich K, Fiaschi-Taesch N, Fischer E, Friedman PA, Karaplis AC, Massfelder T, Rossert J, Schlüter KD, Silve C, Stewart AF, Takane K, Helwig JJ. Clemens TL, et al. Br J Pharmacol. 2001 Nov;134(6):1113-36. doi: 10.1038/sj.bjp.0704378. Br J Pharmacol. 2001. PMID: 11704631 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials