Position-based sequence weights - PubMed (original) (raw)

Comparative Study

. 1994 Nov 4;243(4):574-8.

doi: 10.1016/0022-2836(94)90032-9.

Affiliations

• PMID: 7966282
• DOI: 10.1016/0022-2836(94)90032-9

Comparative Study

Position-based sequence weights

S Henikoff et al. J Mol Biol. 1994.

Abstract

Sequence weighting methods have been used to reduce redundancy and emphasize diversity in multiple sequence alignment and searching applications. Each of these methods is based on a notion of distance between a sequence and an ancestral or generalized sequence. We describe a different approach, which bases weights on the diversity observed at each position in the alignment, rather than on a sequence distance measure. These position-based weights make minimal assumptions, are simple to compute, and perform well in comprehensive evaluations.

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