Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen - PubMed (original) (raw)

. 1994 Nov 25;266(5189):1376-80.

doi: 10.1126/science.7973727.

Affiliations

• PMID: 7973727
• DOI: 10.1126/science.7973727

Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen

M L Smith et al. Science. 1994.

Abstract

GADD45 is a ubiquitously expressed mammalian gene that is induced by DNA damage and certain other stresses. Like another p53-regulated gene, p21WAF1/CIP1, whose product binds to cyclin-dependent kinases (Cdk's) and proliferating cell nuclear antigen (PCNA), GADD45 has been associated with growth suppression. Gadd45 was found to bind to PCNA, a normal component of Cdk complexes and a protein involved in DNA replication and repair. Gadd45 stimulated DNA excision repair in vitro and inhibited entry of cells into S phase. These results establish GADD45 as a link between the p53-dependent cell cycle checkpoint and DNA repair.

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Comment in

• Does the p53 up-regulated Gadd45 protein have a role in excision repair?
  Kazantsev A, Sancar A. Kazantsev A, et al. Science. 1995 Nov 10;270(5238):1003-4; author reply 1005-6. Science. 1995. PMID: 7481776 No abstract available.
• Does the p53 up-regulated Gadd45 protein have a role in excision repair?
  Kearsey JM, Shivji MK, Hall PA, Wood RD. Kearsey JM, et al. Science. 1995 Nov 10;270(5238):1004-5; author reply 1005-6. Science. 1995. PMID: 7481777 No abstract available.
• New link found between p53 and DNA repair.
  Marx J. Marx J. Science. 1994 Nov 25;266(5189):1321-2. doi: 10.1126/science.7973719. Science. 1994. PMID: 7973719 No abstract available.

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