The association of a codon 136 PrP gene variant with the occurrence of natural scrapie - PubMed (original) (raw)

The association of a codon 136 PrP gene variant with the occurrence of natural scrapie

N Hunter et al. Arch Virol. 1994.

Abstract

Incidence of both experimental and natural scrapie in sheep has been associated with polymorphisms of the PrP gene. In case/control studies the PrP allele which encodes valine at codon 136 (Val136) is found in 96-100% of naturally infected scrapie sheep of Shetland, Scottish Halfbred and Blue du Maine breeds. In contrast, in healthy animals from the same flocks, the most frequent allele encodes Ala136 (91-100% of sheep). However Val136 does not correlate with incidence of scrapie in two other flocks--Poll Dorsets and Suffolks--and there may therefore be breed differences in PrP genotypes affected by scrapie.

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