Transmission of tuberculosis in New York City. An analysis by DNA fingerprinting and conventional epidemiologic methods - PubMed (original) (raw)
. 1994 Jun 16;330(24):1710-6.
doi: 10.1056/NEJM199406163302403.
Affiliations
- PMID: 7993412
- DOI: 10.1056/NEJM199406163302403
Free article
Transmission of tuberculosis in New York City. An analysis by DNA fingerprinting and conventional epidemiologic methods
D Alland et al. N Engl J Med. 1994.
Free article
Abstract
Background: The incidence of tuberculosis and drug resistance is increasing in the United States, but it is not clear how much of the increase is due to reactivation of latent infection and how much to recent transmission.
Methods: We performed DNA fingerprinting using restriction-fragment-length polymorphism (RFLP) analysis of at least one isolate from every patient with confirmed tuberculosis at a major hospital in the Bronx, New York, from December 1, 1989, through December 31, 1992. Medical records and census-tract data were reviewed for relevant clinical, social, and demographic data.
Results: Of 130 patients with tuberculosis, 104 adults (80 percent) had complete medical records and isolates whose DNA fingerprints could be evaluated. Isolates from 65 patients (62.5 percent) had unique RFLP patterns, whereas isolates from 39 patients (37.5 percent) had RFLP patterns that were identical to those of an isolate from at least 1 other study patient; the isolates in the latter group were classified into 12 clusters. Patients whose isolates were included in one of the clusters were inferred to have recently transmitted disease. Independent risk factors for having a clustered isolate included seropositivity for the human immunodeficiency virus (HIV) (odds ratio for Hispanic patients, 4.31; P = 0.02; for non-Hispanic patients, 3.12; P = 0.07), Hispanic ethnicity combined with HIV seronegativity (odds ratio, 5.13; P = 0.05), infection with drug-resistant tuberculosis (odds ratio, 4.52; P = 0.005), and younger age (odds ratio, 1.59; P = 0.02). Residence in sections of the Bronx with a median household income below $20,000 was also associated with having a clustered isolate (odds ratio, 3.22; P = 0.04).
Conclusions: In the inner-city community we studied, recently transmitted tuberculosis accounts for approximately 40 percent of the incident cases and almost two thirds of drug-resistant cases. Recent transmission of tuberculosis, and not only reactivation of latent disease, contributes substantially to the increase in tuberculosis.
Comment in
- Tuberculosis transmission in the 1990s.
Hamburg MA, Frieden TR. Hamburg MA, et al. N Engl J Med. 1994 Jun 16;330(24):1750-1. doi: 10.1056/NEJM199406163302410. N Engl J Med. 1994. PMID: 7910663 No abstract available. - Transmission of tuberculosis.
McKenna M. McKenna M. N Engl J Med. 1994 Oct 20;331(16):1093-4; author reply 1094-5. doi: 10.1056/NEJM199410203311614. N Engl J Med. 1994. PMID: 7993478 No abstract available. - Transmission of tuberculosis.
Williams MH Jr. Williams MH Jr. N Engl J Med. 1994 Oct 20;331(16):1094; author reply 1094-5. N Engl J Med. 1994. PMID: 8090176 No abstract available.
Similar articles
- The epidemiology of tuberculosis in San Francisco. A population-based study using conventional and molecular methods.
Small PM, Hopewell PC, Singh SP, Paz A, Parsonnet J, Ruston DC, Schecter GF, Daley CL, Schoolnik GK. Small PM, et al. N Engl J Med. 1994 Jun 16;330(24):1703-9. doi: 10.1056/NEJM199406163302402. N Engl J Med. 1994. PMID: 7910661 - Determination of drug susceptibility and DNA fingerprint patterns of clinical isolates of Mycobacterium tuberculosis from Kampala, Uganda.
Joloba ML, Whalen CC, Cave DM, Eisenach KD, Johnson JL, Okwera A, Morrissey A, Bajaksouzian S, Feagin J, Mugerwa R, Ellner J, Jacobs MR. Joloba ML, et al. East Afr Med J. 2000 Feb;77(2):111-5. East Afr Med J. 2000. PMID: 10774085 - Exogenous reinfection with multidrug-resistant Mycobacterium tuberculosis in patients with advanced HIV infection.
Small PM, Shafer RW, Hopewell PC, Singh SP, Murphy MJ, Desmond E, Sierra MF, Schoolnik GK. Small PM, et al. N Engl J Med. 1993 Apr 22;328(16):1137-44. doi: 10.1056/NEJM199304223281601. N Engl J Med. 1993. PMID: 8096066 - Analysis of tuberculosis transmission between nationalities in the Netherlands in the period 1993-1995 using DNA fingerprinting.
Borgdorff MW, Nagelkerke N, van Soolingen D, de Haas PE, Veen J, van Embden JD. Borgdorff MW, et al. Am J Epidemiol. 1998 Jan 15;147(2):187-95. doi: 10.1093/oxfordjournals.aje.a009433. Am J Epidemiol. 1998. PMID: 9457010 Review.
Cited by
- Genotypic and spatial analysis of transmission dynamics of tuberculosis in Shanghai, China: a 10-year prospective population-based surveillance study.
Li M, Lu L, Jiang Q, Jiang Y, Yang C, Li J, Zhang Y, Zou J, Li Y, Dai W, Hong J, Takiff H, Shen X, Guo X, Yuan Z, Gao Q. Li M, et al. Lancet Reg Health West Pac. 2023 Jun 29;38:100833. doi: 10.1016/j.lanwpc.2023.100833. eCollection 2023 Sep. Lancet Reg Health West Pac. 2023. PMID: 37790084 Free PMC article. - The Mycobacterium tuberculosis genome at 25 years: lessons and lingering questions.
Koleske BN, Jacobs WR Jr, Bishai WR. Koleske BN, et al. J Clin Invest. 2023 Oct 2;133(19):e173156. doi: 10.1172/JCI173156. J Clin Invest. 2023. PMID: 37781921 Free PMC article. Review. - Discrepancy in the transmissibility of multidrug-resistant mycobacterium tuberculosis in urban and rural areas in China.
Li M, Lu L, Guo M, Jiang Q, Xia L, Jiang Y, Zhang S, Qiu Y, Yang C, Chen Y, Hong J, Guo X, Takiff H, Shen X, Chen C, Gao Q. Li M, et al. Emerg Microbes Infect. 2023 Dec;12(1):2192301. doi: 10.1080/22221751.2023.2192301. Emerg Microbes Infect. 2023. PMID: 36924242 Free PMC article. - Bibliometric analysis of tuberculosis molecular epidemiology based on CiteSpace.
Zheng MQ, Li XX, Xu R, Liu S, Rui ZY, Guo ZY, Chen D. Zheng MQ, et al. Front Public Health. 2022 Nov 22;10:1040176. doi: 10.3389/fpubh.2022.1040176. eCollection 2022. Front Public Health. 2022. PMID: 36483245 Free PMC article. - Phylogenetic lineages of tuberculosis isolates and their association with patient demographics in Tanzania.
Mutayoba BK, Michael Hoelscher, Heinrich N, Joloba ML, Lyamuya E, Kilale AM, Range NS, Ngowi BJ, Ntinginya NE, Mfaume SM, Wilfred A, Doulla B, Lyimo J, Kisonga R, Kingalu A, Kabahita JM, Guido O, Kabugo J, Adam I, Luutu M, Namaganda MM, Namutebi J, Kasule GW, Nakato H, Byabajungu H, Lutaaya P, Musisi K, Oola D, Mboowa G, Pletschette M. Mutayoba BK, et al. BMC Genomics. 2022 Aug 5;23(1):561. doi: 10.1186/s12864-022-08791-3. BMC Genomics. 2022. PMID: 35931954 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources