Non-cytolytic CD8 T-cell anti-HIV responses in primary HIV-1 infection - PubMed (original) (raw)
Non-cytolytic CD8 T-cell anti-HIV responses in primary HIV-1 infection
C E Mackewicz et al. Lancet. 1994.
Abstract
Acute HIV infection is accompanied by a sharp rise in virus titres that soon fall, but the role of humoral and cellular immunity is not clear in the control of initial virus replication. We have found seven HIV-1 infected subjects who had CD8 T-cell non-cytolytic anti-HIV activity in plasma many months before neutralising antibodies can be detected. We observed an inverse relation between the extent of this CD8 cell response and the level of plasma viraemia in some subjects. These results suggest that a cellular immune response controls viral replication soon after HIV infection.
Similar articles
- Suppression of HIV replication by lymphoid tissue CD8+ cells correlates with the clinical state of HIV-infected individuals.
Blackbourn DJ, Mackewicz CE, Barker E, Hunt TK, Herndier B, Haase AT, Levy JA. Blackbourn DJ, et al. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13125-30. doi: 10.1073/pnas.93.23.13125. Proc Natl Acad Sci U S A. 1996. PMID: 8917555 Free PMC article. - Viremia control despite escape from a rapid and potent autologous neutralizing antibody response after therapy cessation in an HIV-1-infected individual.
Montefiori DC, Altfeld M, Lee PK, Bilska M, Zhou J, Johnston MN, Gao F, Walker BD, Rosenberg ES. Montefiori DC, et al. J Immunol. 2003 Apr 1;170(7):3906-14. doi: 10.4049/jimmunol.170.7.3906. J Immunol. 2003. PMID: 12646660 - Correlation of CD8 lymphocyte activation with cellular viremia and plasma HIV RNA levels in asymptomatic patients infected by human immunodeficiency virus type 1.
Bouscarat F, Levacher-Clergeot M, Dazza MC, Strauss KW, Girard PM, Ruggeri C, Sinet M. Bouscarat F, et al. AIDS Res Hum Retroviruses. 1996 Jan 1;12(1):17-24. doi: 10.1089/aid.1996.12.17. AIDS Res Hum Retroviruses. 1996. PMID: 8825614 - Immunodominance of HIV-1-specific CD8(+) T-cell responses in acute HIV-1 infection: at the crossroads of viral and host genetics.
Lichterfeld M, Yu XG, Le Gall S, Altfeld M. Lichterfeld M, et al. Trends Immunol. 2005 Mar;26(3):166-71. doi: 10.1016/j.it.2005.01.003. Trends Immunol. 2005. PMID: 15745859 Review. - Viral Inhibitory Activity of CD8+ T Cells in HIV Infection.
Pannus P, Vanham G. Pannus P, et al. AIDS Rev. 2019;21(3):115-125. doi: 10.24875/AIDSRev.19000068. AIDS Rev. 2019. PMID: 31532399 Review.
Cited by
- Effector cell mediated cytotoxicity measured by intracellular Granzyme B release in HIV infected subjects.
Mahajan SD, Aalinkeel R, Schwartz SA, Chawda RP, Nair MP. Mahajan SD, et al. Biol Proced Online. 2003;5:182-188. doi: 10.1251/bpo60. Epub 2003 Sep 5. Biol Proced Online. 2003. PMID: 14615814 Free PMC article. - Immune dysregulation and CD4+ T cell loss in HIV-1 infection.
Meyaard L, Miedema F. Meyaard L, et al. Springer Semin Immunopathol. 1997;18(3):285-303. doi: 10.1007/BF00813499. Springer Semin Immunopathol. 1997. PMID: 9089950 Review. No abstract available. - Autologous and heterologous neutralizing antibody responses following initial seroconversion in human immunodeficiency virus type 1-infected individuals.
Moog C, Fleury HJ, Pellegrin I, Kirn A, Aubertin AM. Moog C, et al. J Virol. 1997 May;71(5):3734-41. doi: 10.1128/JVI.71.5.3734-3741.1997. J Virol. 1997. PMID: 9094648 Free PMC article. - Effect of IL-2 therapy on CD8+ cell noncytotoxic anti-HIV response during primary HIV-1 infection.
Martinez-Mariño B, Ashlock BM, Shiboski S, Hecht FM, Levy JA. Martinez-Mariño B, et al. J Clin Immunol. 2004 Mar;24(2):135-44. doi: 10.1023/B:JOCI.0000019778.96564.26. J Clin Immunol. 2004. PMID: 15024180 Clinical Trial. - Kinetics of cytokine expression during primary human immunodeficiency virus type 1 infection.
Graziosi C, Gantt KR, Vaccarezza M, Demarest JF, Daucher M, Saag MS, Shaw GM, Quinn TC, Cohen OJ, Welbon CC, Pantaleo G, Fauci AS. Graziosi C, et al. Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4386-91. doi: 10.1073/pnas.93.9.4386. Proc Natl Acad Sci U S A. 1996. PMID: 8633076 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials