Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud - PubMed (original) (raw)
Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud
E Laufer et al. Cell. 1994.
Abstract
Proper limb growth and patterning requires signals from the zone of polarizing activity in the posterior mesoderm and from the overlying apical ectodermal ridge (AER). Sonic hedgehog and Fgf-4, respectively, have recently been identified as candidates for these signals. We have dissected the roles of these secreted proteins in early limb development by ectopically regulating their activities in a number of surgical contexts. Our results indicate that Sonic hedgehog initiates expression of secondary signaling molecules, including Bmp-2 in the mesoderm and Fgf-4 in the ectoderm. The mesoderm requires ectodermally derived competence factors, which include Fgf-4, to activate target gene expression in response to Sonic hedgehog. The expression of Sonic hedgehog and Fgf-4 is coordinately regulated by a positive feedback loop operating between the posterior mesoderm and the overlying AER. Taken together, these data provide a basis for understanding the integration of growth and patterning in the developing limb.
Similar articles
- Expression of genes encoding bone morphogenetic proteins and sonic hedgehog in talpid (ta3) limb buds: their relationships in the signalling cascade involved in limb patterning.
Francis-West PH, Robertson KE, Ede DA, Rodriguez C, Izpisúa-Belmonte JC, Houston B, Burt DW, Gribbin C, Brickell PM, Tickle C. Francis-West PH, et al. Dev Dyn. 1995 Jun;203(2):187-97. doi: 10.1002/aja.1002030207. Dev Dyn. 1995. PMID: 7655081 - Synergistic effects of FGF and non-ridge ectoderm on gene expression involved in the formation of the anteroposterior axis of the chick limb bud in cell culture.
Kimura J, Sato-Maeda M, Noji S, Ide H. Kimura J, et al. Dev Growth Differ. 2000 Jun;42(3):219-27. doi: 10.1046/j.1440-169x.2000.00512.x. Dev Growth Differ. 2000. PMID: 10910128 - Shh, Bmp-2 and Hoxd-13 gene expression in chick limb bud cells in culture.
Kimura J, Ide H. Kimura J, et al. Dev Growth Differ. 1998 Aug;40(4):457-64. doi: 10.1046/j.1440-169x.1998.t01-2-00011.x. Dev Growth Differ. 1998. PMID: 9727360 - Mechanisms of limb patterning.
Johnson RL, Riddle RD, Tabin CJ. Johnson RL, et al. Curr Opin Genet Dev. 1994 Aug;4(4):535-42. doi: 10.1016/0959-437x(94)90069-f. Curr Opin Genet Dev. 1994. PMID: 7950321 Review. - Apical ectodermal ridge regulates three principal axes of the developing limb.
Lin GH, Zhang L. Lin GH, et al. J Zhejiang Univ Sci B. 2020 Oct.;21(10):757-766. doi: 10.1631/jzus.B2000285. J Zhejiang Univ Sci B. 2020. PMID: 33043642 Free PMC article. Review.
Cited by
- Fgf signalling triggers an intrinsic mesodermal timer that determines the duration of limb patterning.
Sedas Perez S, McQueen C, Stainton H, Pickering J, Chinnaiya K, Saiz-Lopez P, Placzek M, Ros MA, Towers M. Sedas Perez S, et al. Nat Commun. 2023 Sep 20;14(1):5841. doi: 10.1038/s41467-023-41457-6. Nat Commun. 2023. PMID: 37730682 Free PMC article. - Feather buds exert a polarizing activity when transplanted to chick limb buds.
Uchiyama K, Yanazawa M, Kuroiwa A, Kitamura K. Uchiyama K, et al. Dev Growth Differ. 1996 Dec;38(6):635-645. doi: 10.1046/j.1440-169X.1996.t01-5-00007.x. Dev Growth Differ. 1996. PMID: 37281919 - A Drosophila receptor-type tyrosine kinase (DFR1) acts as a fibroblast growth factor receptor in Xenopus embryos.
Yoshioka H, Ohuchi H, Ishimaru Y, Ishikawa T, Nohno T, Saigo K, Noji S. Yoshioka H, et al. Dev Growth Differ. 1996 Dec;38(6):617-624. doi: 10.1046/j.1440-169X.1996.t01-5-00005.x. Dev Growth Differ. 1996. PMID: 37281644 - Developmental regulation of conserved non-coding element evolution provides insights into limb loss in squamates.
Wang Z, Peng C, Wu W, Yan C, Lv Y, Li JT. Wang Z, et al. Sci China Life Sci. 2023 Oct;66(10):2399-2414. doi: 10.1007/s11427-023-2362-5. Epub 2023 May 22. Sci China Life Sci. 2023. PMID: 37256419 - The role of timing in the development and evolution of the limb.
Zhu M, Tabin CJ. Zhu M, et al. Front Cell Dev Biol. 2023 May 2;11:1135519. doi: 10.3389/fcell.2023.1135519. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 37200627 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources