Maternal rescue of transforming growth factor-beta 1 null mice - PubMed (original) (raw)

. 1994 Jun 24;264(5167):1936-8.

doi: 10.1126/science.8009224.

Affiliations

• PMID: 8009224
• DOI: 10.1126/science.8009224

Maternal rescue of transforming growth factor-beta 1 null mice

J J Letterio et al. Science. 1994.

Abstract

Maternal sources of transforming growth factor-beta 1 (TGF-beta 1) are shown here to contribute to the normal appearance and perinatal survival of TGF-beta 1 null newborn mice. Labeled TGF-beta 1 crossed the placenta and was recovered intact from various tissues after oral administration to mouse pups. TGF beta-1 protein was also detected in cells recovered from breast milk. In immunohistochemical analyses, TGF-beta 1 null embryos and null newborn pups born to TGF-beta 1 heterozygotes stained positive for TGF-beta 1, whereas those born to a null female were negative and had severe cardiac abnormalities. These results suggest an important role for maternal sources of TGF-beta 1 during development and, more generally, provide evidence for maternal rescue of targeted gene disruption in the fetus.

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