In vivo versus in vitro assays for assessment of T- and B- cell function - PubMed (original) (raw)

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In vivo versus in vitro assays for assessment of T- and B- cell function

M F Bachmann et al. Curr Opin Immunol. 1994 Apr.

Abstract

As mice deficient in a particular gene provide an increasing number of novel in vivo models, in vivo assays that examine immune function are becoming a central issue. We found that the sensitivities of in vivo and in vitro assays are strikingly different. These differences have important implications for the interpretation and biological relevance of results.

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