Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting - PubMed (original) (raw)
. 1994 Jul 1;265(5168):103-6.
doi: 10.1126/science.8016642.
Affiliations
- PMID: 8016642
- DOI: 10.1126/science.8016642
Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting
H Gu et al. Science. 1994.
Abstract
Deletion of the promoter and the first exon of the DNA polymerase beta gene (pol beta) in the mouse germ line results in a lethal phenotype. With the use of the bacteriophage-derived, site-specific recombinase Cre in a transgenic approach, the same mutation can be selectively introduced into a particular cellular compartment-in this case, T cells. The impact of the mutation on those cells can then be analyzed because the mutant animals are viable.
Comment in
- Knockout mice: round two.
Barinaga M. Barinaga M. Science. 1994 Jul 1;265(5168):26-8. doi: 10.1126/science.8016653. Science. 1994. PMID: 8016653 No abstract available.
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