Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens - PubMed (original) (raw)

. 1993 Dec 17;262(5141):1892-5.

doi: 10.1126/science.8018146.

Affiliations

• PMID: 8018146
• DOI: 10.1126/science.8018146

Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens

T Borén et al. Science. 1993.

Abstract

Helicobacter pylori is associated with development of gastritis, gastric ulcers, and adenocarcinomas in humans. The Lewis(b) (Le(b)) blood group antigen mediates H. pylori attachment to human gastric mucosa. Soluble glycoproteins presenting the Leb antigen or antibodies to the Leb antigen inhibited bacterial binding. Gastric tissue lacking Leb expression did not bind H. pylori. Bacteria did not bind to Leb antigen substituted with a terminal GalNAc alpha 1-3 residue (blood group A determinant), suggesting that the availability of H. pylori receptors might be reduced in individuals of blood group A and B phenotypes, as compared with blood group O individuals.

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Comment in

• Blood type and the risk of gastric disease.
  Hallstone AE, Perez EA. Hallstone AE, et al. Science. 1994 Jun 3;264(5164):1386-8. Science. 1994. PMID: 8197448 No abstract available.
• New bind for ulcer bacterium.
  Alper J. Alper J. Science. 1993 Dec 17;262(5141):1817. doi: 10.1126/science.8266067. Science. 1993. PMID: 8266067 No abstract available.

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