Growth-promoting effects of glycine-extended progastrin - PubMed (original) (raw)
Comparative Study
. 1994 Jul 15;265(5170):410-2.
doi: 10.1126/science.8023165.
Affiliations
- PMID: 8023165
- DOI: 10.1126/science.8023165
Comparative Study
Growth-promoting effects of glycine-extended progastrin
C Seva et al. Science. 1994.
Abstract
Peptide alpha amidation is required to produce some hormones, such as gastrin, from their glycine-extended precursors. This terminal posttranslational processing reaction is thought to be essential for the biological activation of many peptide hormones; only amidated gastrin exerts a physiological effect that results in gastric acid secretion. However, both amidated gastrin and glycine-extended gastrin stimulate proliferation of exocrine pancreatic cell line AR4-2J through selective receptors for the substrate and the product, respectively, of peptide alpha amidation. Thus, the amidation reaction may function as a determinant of the specific biological actions of products derived from prohormones.
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