Structure and mechanism of interleukin-1 beta converting enzyme - PubMed (original) (raw)

. 1994 Jul 28;370(6487):270-5.

doi: 10.1038/370270a0.

Affiliations

• PMID: 8035875
• DOI: 10.1038/370270a0

Structure and mechanism of interleukin-1 beta converting enzyme

K P Wilson et al. Nature. 1994.

Abstract

Interleukin-1 beta converting enzyme (ICE) processes an inactive precursor to the proinflammatory cytokine, interleukin-1 beta, and may regulate programmed cell death in neuronal cells. The high-resolution structure of human ICE in complex with an inhibitor has been determined by X-ray diffraction. The structure confirms the relationship between human ICE and cell-death proteins in other organisms. The active site spans both the 10 and 20K subunits, which associate to form a tetramer, suggesting a mechanism for ICE autoactivation.

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Comment in

• Inflammation. Key mediator takes shape.
  Thornberry NA. Thornberry NA. Nature. 1994 Jul 28;370(6487):251-2. doi: 10.1038/370251a0. Nature. 1994. PMID: 8035871 No abstract available.

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