Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog - PubMed (original) (raw)
. 1994 Jul 29;265(5172):682-4.
doi: 10.1126/science.8036519.
Affiliations
- PMID: 8036519
- DOI: 10.1126/science.8036519
Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog
G Cacalano et al. Science. 1994.
Erratum in
- Science 1995 Oct 20;270(5235):365
Abstract
Interleukin-8 (IL-8) is a proinflammatory cytokine that specifically attracts and activates human neutrophils. A murine gene with a high degree of homology to the two known human IL-8 receptors was cloned and then deleted from the mouse genome by homologous recombination in embryonic stem (ES) cells. These mice, although outwardly healthy, had lymphadenopathy, resulting from an increase in B cells, and splenomegaly, resulting from an increase in metamyelocytes, band, and mature neutrophils. Thus, this receptor may participate in the expansion and development of neutrophils and B cells. This receptor was the major mediator of neutrophil migration to sites of inflammation and may provide a potential therapeutic target in inflammatory disease.
Comment in
- Neutrophilia in mice that lack the murine IL-8 receptor homolog.
Shuster DE, Kehrli ME Jr, Ackermann MR. Shuster DE, et al. Science. 1995 Sep 15;269(5230):1590-1. doi: 10.1126/science.7667641. Science. 1995. PMID: 7667641 No abstract available.
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