Participation of cyclin A in Myc-induced apoptosis - PubMed (original) (raw)

Participation of cyclin A in Myc-induced apoptosis

A T Hoang et al. Proc Natl Acad Sci U S A. 1994.

Abstract

The involvement of c-Myc in cellular proliferation or apoptosis has been linked to differential cyclin gene expression. We observed that in both proliferating cells and cells undergoing apoptosis, cyclin A (but not B, C, D1, and E) mRNA level was elevated in unsynchronized Myc-overexpressing cells when compared with parental Rat1a fibroblasts. We further demonstrated that Zn(2+)-inducible cyclin A expression was sufficient to cause apoptosis. When Myc-induced apoptosis was blocked by coexpression of Bcl-2, the levels of cyclin C, D1, and E mRNAs were also elevated. Thus, while apoptosis induced by c-Myc is associated with an elevated cyclin A mRNA level, protection from apoptosis by coexpressed Bcl-2 is associated with a complementary increase in cyclin C, D1, and E mRNAs.

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References

    1. Nature. 1992 Oct 8;359(6395):554-6 - PubMed
    1. Nature. 1992 Oct 8;359(6395):552-4 - PubMed
    1. Cell. 1993 Aug 13;74(3):463-74 - PubMed
    1. Mol Cell Biol. 1993 Dec;13(12):7358-63 - PubMed
    1. Science. 1993 Dec 3;262(5139):1572-5 - PubMed

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