Phosphatidylinositol-3-OH kinase as a direct target of Ras - PubMed (original) (raw)

. 1994 Aug 18;370(6490):527-32.

doi: 10.1038/370527a0.

Affiliations

• PMID: 8052307
• DOI: 10.1038/370527a0

Phosphatidylinositol-3-OH kinase as a direct target of Ras

P Rodriguez-Viciana et al. Nature. 1994.

Abstract

Ras (p21ras) interacts directly with the catalytic subunit of phosphatidylinositol-3-OH kinase in a GTP-dependent manner through the Ras effector site. In vivo, dominant negative Ras mutant N17 inhibits growth factor induced production of 3' phosphorylated phosphoinositides in PC12 cells, and transfection of Ras, but not Raf, into COS cells results in a large elevation in the level of these lipids. Therefore Ras can probably regulate phosphatidylinositol-3-OH kinase, providing a point of divergence in signalling pathways downstream of Ras.

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Comment in

• Signal transduction. The hunt for Ras targets.
  Feig LA, Schaffhausen B. Feig LA, et al. Nature. 1994 Aug 18;370(6490):508-9. doi: 10.1038/370508a0. Nature. 1994. PMID: 8052306 No abstract available.

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