Bcl-2 inhibits T-cell-mediated cytolysis of a leukemia cell line - PubMed (original) (raw)
. 1994 Sep 15;54(18):4851-4.
Affiliations
- PMID: 8069851
Bcl-2 inhibits T-cell-mediated cytolysis of a leukemia cell line
T Torigoe et al. Cancer Res. 1994.
Abstract
The bcl-2 gene becomes dysregulated in its expression in a wide variety of human cancers and has been shown to block both spontaneous and drug-induced cell death, thus conferring a selective survival advantage on malignant cells. The biochemical mechanism by which bcl-2 promotes cell survival remains enigmatic but appears to involve a downstream event in an evolutionarily conserved cell death pathway. Here we report that gene transfer-mediated increases in Bcl-2 protein levels in the human leukemia line Jurkat render these cells more resistant to induction of DNA fragmentation and cytolysis by a cloned T-cell. The killing mechanism used by these particular T-cells was consistent with apoptosis, as opposed to necrosis, in that DNA degradation occurred as a prelysis event. The findings raise the possibility that dysregulation of bcl-2 gene expression could play a role in the avoidance of immune surveillance mechanisms by cancer cells.
Similar articles
- Suppression of Bcl-2 messenger RNA production may mediate apoptosis after ionizing radiation, tumor necrosis factor alpha, and ceramide.
Chen M, Quintans J, Fuks Z, Thompson C, Kufe DW, Weichselbaum RR. Chen M, et al. Cancer Res. 1995 Mar 1;55(5):991-4. Cancer Res. 1995. PMID: 7867010 - Bcl-2 expression inhibits prostaglandin E2-mediated apoptosis in B cell lymphomas.
Brown DM, Phipps RP. Brown DM, et al. J Immunol. 1996 Aug 15;157(4):1359-70. J Immunol. 1996. PMID: 8759715 - Cell injury and apoptosis.
Liepins A, Bustamante JO. Liepins A, et al. Scanning Microsc. 1994;8(3):631-41; discussion 641-3. Scanning Microsc. 1994. PMID: 7747162 Review. - Differentiation and cell death: lessons from the immune system.
Linette GP, Korsmeyer SJ. Linette GP, et al. Curr Opin Cell Biol. 1994 Dec;6(6):809-15. doi: 10.1016/0955-0674(94)90049-3. Curr Opin Cell Biol. 1994. PMID: 7880527 Review.
Cited by
- Small-molecule Bcl-2 inhibitors sensitise tumour cells to immune-mediated destruction.
Lickliter JD, Cox J, McCarron J, Martinez NR, Schmidt CW, Lin H, Nieda M, Nicol AJ. Lickliter JD, et al. Br J Cancer. 2007 Feb 26;96(4):600-8. doi: 10.1038/sj.bjc.6603599. Br J Cancer. 2007. PMID: 17311012 Free PMC article. - Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells.
Carter BZ, Gronda M, Wang Z, Welsh K, Pinilla C, Andreeff M, Schober WD, Nefzi A, Pond GR, Mawji IA, Houghten RA, Ostresh J, Brandwein J, Minden MD, Schuh AC, Wells RA, Messner H, Chun K, Reed JC, Schimmer AD. Carter BZ, et al. Blood. 2005 May 15;105(10):4043-50. doi: 10.1182/blood-2004-08-3168. Epub 2005 Feb 1. Blood. 2005. PMID: 15687241 Free PMC article. - Microtubule-targeting drugs induce bcl-2 phosphorylation and association with Pin1.
Pathan N, Aime-Sempe C, Kitada S, Basu A, Haldar S, Reed JC. Pathan N, et al. Neoplasia. 2001 Nov-Dec;3(6):550-9. doi: 10.1038/sj.neo.7900213. Neoplasia. 2001. PMID: 11774038 Free PMC article. - Microtubule-targeting drugs induce Bcl-2 phosphorylation and association with Pin1.
Pathan N, Aime-Sempe C, Kitada S, Haldar S, Reed JC. Pathan N, et al. Neoplasia. 2001 Jan-Feb;3(1):70-9. doi: 10.1038/sj.neo.7900131. Neoplasia. 2001. PMID: 11326318 Free PMC article. - BAR: An apoptosis regulator at the intersection of caspases and Bcl-2 family proteins.
Zhang H, Xu Q, Krajewski S, Krajewska M, Xie Z, Fuess S, Kitada S, Pawlowski K, Godzik A, Reed JC. Zhang H, et al. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2597-602. doi: 10.1073/pnas.97.6.2597. Proc Natl Acad Sci U S A. 2000. PMID: 10716992 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical