Isolation of a novel gene mutated in Wiskott-Aldrich syndrome - PubMed (original) (raw)
Isolation of a novel gene mutated in Wiskott-Aldrich syndrome
J M Derry et al. Cell. 1994.
Erratum in
- Isolation of a novel gene mutated in Wiskott-Aldrich syndrome.
Derry JM, Ochs HD, Francke U. Derry JM, et al. Cell. 1994 Dec 2;79(5):following 922. Cell. 1994. PMID: 8001129 No abstract available.
Abstract
Wiskott-Aldrich syndrome (WAS) is an X-linked recessive immunodeficiency characterized by eczema, thrombocytopenia, and recurrent infections. Linkage studies have placed the gene at Xp11.22-p11.23. We have isolated from this interval a novel gene, WASP, which is expressed in lymphocytes, spleen, and thymus. The gene is not expressed in two unrelated WAS patients, one of whom has a single base deletion that produces a frame shift and premature termination of translation. Two additional patients have been identified with point mutations that change the same arginine residue to either a histidine or a leucine. WASP encodes a 501 amino acid proline-rich protein that is likely to be a key regulator of lymphocyte and platelet function.
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