Epidermal growth factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver - PubMed (original) (raw)
. 1994 Sep 2;269(35):21933-5.
Affiliations
- PMID: 8071311
Free article
Epidermal growth factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver
S Ruff-Jamison et al. J Biol Chem. 1994.
Free article
Abstract
Previous studies demonstrated that the intraperitoneal injection of epidermal growth factor (EGF) into mice resulted in the appearance, within minutes, of several tyrosine-phosphorylated proteins in liver nuclei. Two of these proteins have been identified as the transcription factors p91/p84 (Stat1 alpha/1 beta) (Ruff-Jamison, S., Chen, K., and Cohen, S. (1993) Science 261, 1733-1736). We have now identified, by Western blotting and immunoprecipitation, an additional EGF-modulated transcription factor, Stat3. We find that Stat3 is tyrosine-phosphorylated and present in mouse liver nuclei following either EGF or lipopolysaccharide administration. Gel shift analyses show that Stat3 is capable of specifically binding the SIE (a DNA sequence present in the c-fos promoter). Three active SIE binding complexes (SIF A, B, and C) exist in the nucleus after the administration of EGF: one complex that contains Stat3, one that contains Stat1, and a third complex that appears to contain both proteins. Only one active SIE binding complex, containing Stat3, was detected after the administration of lipopolysaccharide.
Similar articles
- Epidermal growth factor induces the tyrosine phosphorylation and nuclear translocation of Stat 5 in mouse liver.
Ruff-Jamison S, Chen K, Cohen S. Ruff-Jamison S, et al. Proc Natl Acad Sci U S A. 1995 May 9;92(10):4215-8. doi: 10.1073/pnas.92.10.4215. Proc Natl Acad Sci U S A. 1995. PMID: 7538664 Free PMC article. - Induction by EGF and interferon-gamma of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei.
Ruff-Jamison S, Chen K, Cohen S. Ruff-Jamison S, et al. Science. 1993 Sep 24;261(5129):1733-6. doi: 10.1126/science.8378774. Science. 1993. PMID: 8378774 - In vivo growth hormone treatment rapidly stimulates the tyrosine phosphorylation and activation of Stat3.
Gronowski AM, Zhong Z, Wen Z, Thomas MJ, Darnell JE Jr, Rotwein P. Gronowski AM, et al. Mol Endocrinol. 1995 Feb;9(2):171-7. doi: 10.1210/mend.9.2.7776967. Mol Endocrinol. 1995. PMID: 7776967 - Pyk2 amplifies epidermal growth factor and c-Src-induced Stat3 activation.
Shi CS, Kehrl JH. Shi CS, et al. J Biol Chem. 2004 Apr 23;279(17):17224-31. doi: 10.1074/jbc.M311875200. Epub 2004 Feb 12. J Biol Chem. 2004. PMID: 14963038 - Regulation of epidermal growth factor receptor by activated H-ras and V-myc oncogenes in mouse Balb/3T3 cells: possible roles of AP-1.
Okimoto T, Kohno K, Kuwano M, Gopas J, Kung HF, Ono M. Okimoto T, et al. Oncogene. 1996 Apr 18;12(8):1625-33. Oncogene. 1996. PMID: 8622882
Cited by
- A Chimeric Egfr Protein Reporter Mouse Reveals Egfr Localization and Trafficking In Vivo.
Yang YP, Ma H, Starchenko A, Huh WJ, Li W, Hickman FE, Zhang Q, Franklin JL, Mortlock DP, Fuhrmann S, Carter BD, Ihrie RA, Coffey RJ. Yang YP, et al. Cell Rep. 2017 May 9;19(6):1257-1267. doi: 10.1016/j.celrep.2017.04.048. Cell Rep. 2017. PMID: 28494873 Free PMC article. - Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins.
Vignais ML, Sadowski HB, Watling D, Rogers NC, Gilman M. Vignais ML, et al. Mol Cell Biol. 1996 Apr;16(4):1759-69. doi: 10.1128/MCB.16.4.1759. Mol Cell Biol. 1996. PMID: 8657151 Free PMC article. - Modeling of tumor progression in NSCLC and intrinsic resistance to TKI in loss of PTEN expression.
Bidkhori G, Moeini A, Masoudi-Nejad A. Bidkhori G, et al. PLoS One. 2012;7(10):e48004. doi: 10.1371/journal.pone.0048004. Epub 2012 Oct 24. PLoS One. 2012. PMID: 23133538 Free PMC article. - STAT signaling in the pathogenesis and treatment of cancer.
Frank DA. Frank DA. Mol Med. 1999 Jul;5(7):432-56. Mol Med. 1999. PMID: 10449805 Free PMC article. Review. - Epidermal growth factor induces the tyrosine phosphorylation and nuclear translocation of Stat 5 in mouse liver.
Ruff-Jamison S, Chen K, Cohen S. Ruff-Jamison S, et al. Proc Natl Acad Sci U S A. 1995 May 9;92(10):4215-8. doi: 10.1073/pnas.92.10.4215. Proc Natl Acad Sci U S A. 1995. PMID: 7538664 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous