Amygdala modulation of hippocampal-dependent and caudate nucleus-dependent memory processes - PubMed (original) (raw)

Amygdala modulation of hippocampal-dependent and caudate nucleus-dependent memory processes

M G Packard et al. Proc Natl Acad Sci U S A. 1994.

Abstract

These experiments investigated the effects, on memory, of injections of d-amphetamine (10 micrograms/0.5 microliter) administered into the amygdala, hippocampus, or caudate nucleus immediately after training in cued or spatial water-maze tasks. In experiment 1, rats received an eight-trial training session on one of the two tasks followed by injections of d-amphetamine or saline. Retention was tested 24 hr later. On the spatial task, intrahippocampal, but not intracaudate, injections of d-amphetamine facilitated retention. In contrast, on the cued task intracaudate, but not intrahippocampal, injections of d-amphetamine facilitated retention. Posttraining intraamygdala injections of d-amphetamine enhanced retention of both tasks. In experiment 2, lidocaine (2% solution; 1.0 microliter) injected intraamygdally prior to the retention test did not block the memory enhancement induced by posttraining intraamygdala injections of d-amphetamine. The findings (i) provide further evidence of a dissociation between the roles of the hippocampus and caudate nucleus in different forms of memory, (ii) indicate that the modulatory role of the amygdala is not limited to either of the two different forms of memory represented in spatial and cued discriminations in a water maze, and (iii) are consistent with previous findings indicating that amygdala influences on memory storage are not mediated by lasting neural changes located within the amygdala.

PubMed Disclaimer

Cited by

Basolateral amygdala inputs to the nucleus accumbens shell modulate the consolidation of cued-response and inhibitory avoidance learning.
Glickman B, Wahlstrom KL, Radley JJ, LaLumiere RT. Glickman B, et al. Neurobiol Learn Mem. 2024 Nov;215:107988. doi: 10.1016/j.nlm.2024.107988. Epub 2024 Oct 5. Neurobiol Learn Mem. 2024. PMID: 39369810
Memory modulation.
Roozendaal B, McGaugh JL. Roozendaal B, et al. Behav Neurosci. 2011 Dec;125(6):797-824. doi: 10.1037/a0026187. Behav Neurosci. 2011. PMID: 22122145 Free PMC article. Review.
The connection between the hippocampal and the striatal memory systems of the brain: a review of recent findings.
Izquierdo I, Bevilaqua LR, Rossato JI, Bonini JS, Da Silva WC, Medina JH, Cammarota M. Izquierdo I, et al. Neurotox Res. 2006 Oct;10(2):113-21. doi: 10.1007/BF03033240. Neurotox Res. 2006. PMID: 17062373 Review.
Reinforcement of early long-term potentiation (early-LTP) in dentate gyrus by stimulation of the basolateral amygdala: heterosynaptic induction mechanisms of late-LTP.
Frey S, Bergado-Rosado J, Seidenbecher T, Pape HC, Frey JU. Frey S, et al. J Neurosci. 2001 May 15;21(10):3697-703. doi: 10.1523/JNEUROSCI.21-10-03697.2001. J Neurosci. 2001. PMID: 11331399 Free PMC article.

References

1. Annu Rev Pharmacol. 1973;13:229-41 - PubMed
1. Behav Neurosci. 1993 Feb;107(1):3-22 - PubMed
1. J Comp Neurol. 1978 Mar 15;178(2):225-54 - PubMed
1. Science. 1980 Oct 10;210(4466):207-10 - PubMed
1. Neuroscience. 1982 Mar;7(3):615-30 - PubMed

Amygdala modulation of hippocampal-dependent and caudate nucleus-dependent memory processes - PubMed (original) (raw)