Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death - PubMed (original) (raw)
Comparative Study
Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death
L Wang et al. Cell. 1994.
Abstract
We report here the isolation and characterization of Ich-1, a gene related to the C. elegans cell death gene ced-3 and the mammalian homolog of ced-3, interleukin-1 beta-converting enzyme (ICE). Alternative splicing results in two distinct Ich-1 mRNA species. One mRNA species encodes a protein product of 435 amino acids (ICH-1L) that is homologous to both the P20 and P10 subunits of ICE (27% identity) and the entire CED-3 protein (28% identity). The other mRNA encodes a 312 amino acid truncated version of ICH-1L protein (ICH-1S). Overexpression of IchL induces programmed cell death, suggesting that Ich-1 is also a mammalian programmed cell death gene. More interestingly, overexpression of the Ich-1S suppresses Rat-1 cell death induced by serum deprivation. These observations suggest that Ich-1 plays an important role in both positive and negative regulation of programmed cell death in vertebrate animals.
Similar articles
- The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme.
Yuan J, Shaham S, Ledoux S, Ellis HM, Horvitz HR. Yuan J, et al. Cell. 1993 Nov 19;75(4):641-52. doi: 10.1016/0092-8674(93)90485-9. Cell. 1993. PMID: 8242740 - Characterization of the avian Ich-1 cDNA and expression of Ich-1L mRNA in the hen ovary.
Johnson AL, Bridgham JT, Bergeron L, Yuan J. Johnson AL, et al. Gene. 1997 Jun 19;192(2):227-33. doi: 10.1016/s0378-1119(97)00068-1. Gene. 1997. PMID: 9224894 - Ced-3/ICE: evolutionarily conserved regulation of cell death.
Schwartz LM, Osborne BA. Schwartz LM, et al. Bioessays. 1994 Jun;16(6):387-9. doi: 10.1002/bies.950160604. Bioessays. 1994. PMID: 8080427 Review. No abstract available. - Genetic control of cellular suicide.
Yuan J. Yuan J. Reprod Toxicol. 1997 Mar-Jun;11(2-3):377-84. doi: 10.1016/s0890-6238(96)00150-5. Reprod Toxicol. 1997. PMID: 9100313 Review.
Cited by
- Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant.
Di Donato N, Jean YY, Maga AM, Krewson BD, Shupp AB, Avrutsky MI, Roy A, Collins S, Olds C, Willert RA, Czaja AM, Johnson R, Stover JA, Gottlieb S, Bartholdi D, Rauch A, Goldstein A, Boyd-Kyle V, Aldinger KA, Mirzaa GM, Nissen A, Brigatti KW, Puffenberger EG, Millen KJ, Strauss KA, Dobyns WB, Troy CM, Jinks RN. Di Donato N, et al. Am J Hum Genet. 2016 Nov 3;99(5):1117-1129. doi: 10.1016/j.ajhg.2016.09.010. Epub 2016 Oct 20. Am J Hum Genet. 2016. PMID: 27773430 Free PMC article. - Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex.
Park HH, Logette E, Raunser S, Cuenin S, Walz T, Tschopp J, Wu H. Park HH, et al. Cell. 2007 Feb 9;128(3):533-46. doi: 10.1016/j.cell.2007.01.019. Cell. 2007. PMID: 17289572 Free PMC article. - Functional divergence in the caspase gene family and altered functional constraints: statistical analysis and prediction.
Wang Y, Gu X. Wang Y, et al. Genetics. 2001 Jul;158(3):1311-20. doi: 10.1093/genetics/158.3.1311. Genetics. 2001. PMID: 11454777 Free PMC article. - Expression of c-Jun and Bcl-2 family proteins in apoptotic photoreceptors of RCS rats.
Katai N, Yanagidaira T, Senda N, Murata T, Yoshimura N. Katai N, et al. Jpn J Ophthalmol. 2006 Mar-Apr;50(2):121-7. doi: 10.1007/s10384-005-0296-7. Jpn J Ophthalmol. 2006. PMID: 16604387 - Heat shock and ceramide have different apoptotic pathways in radiation induced fibrosarcoma (RIF) cells.
Kim HJ, Lee KJ. Kim HJ, et al. Mol Cell Biochem. 2002 Jan;229(1-2):139-51. doi: 10.1023/a:1017941131744. Mol Cell Biochem. 2002. PMID: 11936839
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases