Cloning of two novel ABC transporters mapping on human chromosome 9 - PubMed (original) (raw)
Comparative Study
. 1994 May 1;21(1):150-9.
doi: 10.1006/geno.1994.1237.
Affiliations
- PMID: 8088782
- DOI: 10.1006/geno.1994.1237
Comparative Study
Cloning of two novel ABC transporters mapping on human chromosome 9
M F Luciani et al. Genomics. 1994.
Abstract
The family of ATP binding cassette (ABC) transporters or traffic ATPases is composed of several membrane-associated proteins that transport a great variety of solutes across cellular membranes. Two novel mammalian members of the family, ABC1 and ABC2, have been identified by a PCR-based approach. They belong to a group of traffic ATPases encoded as a single multifunctional protein, such as CFTR, STE 6, and P-glycoproteins. Their peculiar structural features and close relationship to ABC transporters involved in nodulation suggest that ABC1 and ABC2 define a novel subgroup of mammalian traffic ATPases.
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