The ancient regulatory-protein family of WD-repeat proteins - PubMed (original) (raw)
Review
. 1994 Sep 22;371(6495):297-300.
doi: 10.1038/371297a0.
Affiliations
- PMID: 8090199
- DOI: 10.1038/371297a0
Review
The ancient regulatory-protein family of WD-repeat proteins
E J Neer et al. Nature. 1994.
Erratum in
- Nature 1994 Oct 27;371(6500):812
Abstract
WD proteins are made up of highly conserved repeating units usually ending with Trp-Asp (WD). They are found in all eukaryotes but not in prokaryotes. They regulate cellular functions, such as cell division, cell-fate determination, gene transcription, transmembrane signalling, mRNA modification and vesicle fusion. Here we define the common features of the repeating units, and criteria for grouping such proteins into functional subfamilies.
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