The morphological effects of the anti-tumor agents flavone acetic acid and 5,6-dimethyl xanthenone acetic acid on the colon 38 mouse tumor - PubMed (original) (raw)
Comparative Study
The morphological effects of the anti-tumor agents flavone acetic acid and 5,6-dimethyl xanthenone acetic acid on the colon 38 mouse tumor
L J Zwi et al. Pathology. 1994 Apr.
Abstract
Flavone acetic acid and 5,6-dimethyl xanthenone acetic acid have a broad spectrum of anti-tumor activity in mice, and act by stimulating immune cells and inhibiting tumor blood flow, resulting in hemorrhagic necrosis within 24 hrs. To study the evolution of hemorrhagic necrosis, subcutaneous Colon 38 tumors were examined by light and electron microscopy from 30 min to 24 hrs after treatment with these agents, and measurements of tumor energy metabolites made. The results show that both agents cause apoptosis beginning at 30 min, and that by 4 hrs necrosis supervenes, accompanied by rupture of tumor blood vessels. The absence of early endothelial cell damage or thrombosis suggests that vessel rupture, and consequent loss of blood flow and energy metabolite depletion, is caused by loss of extravascular mechanical support by the tumor parenchyma.
Similar articles
- Induction of endothelial cell apoptosis by the antivascular agent 5,6-Dimethylxanthenone-4-acetic acid.
Ching LM, Cao Z, Kieda C, Zwain S, Jameson MB, Baguley BC. Ching LM, et al. Br J Cancer. 2002 Jun 17;86(12):1937-42. doi: 10.1038/sj.bjc.6600368. Br J Cancer. 2002. PMID: 12085190 Free PMC article. Clinical Trial. - Necrosis in non-tumour tissues caused by flavone acetic acid and 5,6-dimethyl xanthenone acetic acid.
Zwi LJ, Baguley BC, Gavin JB, Wilson WR. Zwi LJ, et al. Br J Cancer. 1990 Dec;62(6):932-4. doi: 10.1038/bjc.1990.412. Br J Cancer. 1990. PMID: 2257222 Free PMC article. No abstract available. - Small-molecule cytokine inducers causing tumor necrosis.
Baguley BC. Baguley BC. Curr Opin Investig Drugs. 2001 Jul;2(7):967-75. Curr Opin Investig Drugs. 2001. PMID: 11757800 Review. - Flavonoid-Inspired Vascular Disrupting Agents: Exploring Flavone-8-Acetic Acid and Derivatives in the New Century.
Gobbi S, Belluti F, Rampa A, Bisi A. Gobbi S, et al. Molecules. 2021 Jul 12;26(14):4228. doi: 10.3390/molecules26144228. Molecules. 2021. PMID: 34299503 Free PMC article. Review.
Cited by
- Aminolevulinic acid-photodynamic therapy combined with topically applied vascular disrupting agent vadimezan leads to enhanced antitumor responses.
Marrero A, Becker T, Sunar U, Morgan J, Bellnier D. Marrero A, et al. Photochem Photobiol. 2011 Jul-Aug;87(4):910-9. doi: 10.1111/j.1751-1097.2011.00943.x. Epub 2011 Jun 13. Photochem Photobiol. 2011. PMID: 21575001 Free PMC article. - The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis.
Roberts ZJ, Goutagny N, Perera PY, Kato H, Kumar H, Kawai T, Akira S, Savan R, van Echo D, Fitzgerald KA, Young HA, Ching LM, Vogel SN. Roberts ZJ, et al. J Exp Med. 2007 Jul 9;204(7):1559-69. doi: 10.1084/jem.20061845. Epub 2007 Jun 11. J Exp Med. 2007. PMID: 17562815 Free PMC article. - 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent: phase I clinical and pharmacokinetic study.
Rustin GJ, Bradley C, Galbraith S, Stratford M, Loadman P, Waller S, Bellenger K, Gumbrell L, Folkes L, Halbert G; Phase I/II Trials Committee of Cancer Research UK. Rustin GJ, et al. Br J Cancer. 2003 Apr 22;88(8):1160-7. doi: 10.1038/sj.bjc.6600885. Br J Cancer. 2003. PMID: 12698178 Free PMC article. Clinical Trial. - Induction of endothelial cell apoptosis by the antivascular agent 5,6-Dimethylxanthenone-4-acetic acid.
Ching LM, Cao Z, Kieda C, Zwain S, Jameson MB, Baguley BC. Ching LM, et al. Br J Cancer. 2002 Jun 17;86(12):1937-42. doi: 10.1038/sj.bjc.6600368. Br J Cancer. 2002. PMID: 12085190 Free PMC article. Clinical Trial. - Enhancement of the anti-tumour effects of the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by combination with 5-hydroxytryptamine and bioreductive drugs.
Lash CJ, Li AE, Rutland M, Baguley BC, Zwi LJ, Wilson WR. Lash CJ, et al. Br J Cancer. 1998 Aug;78(4):439-45. doi: 10.1038/bjc.1998.512. Br J Cancer. 1998. PMID: 9716024 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources