Regression of small-cell lung carcinoma in patients with paraneoplastic neuronal antibodies - PubMed (original) (raw)

Case Reports

. 1993 Jan 2;341(8836):21-2.

doi: 10.1016/0140-6736(93)92485-c.

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Case Reports

Regression of small-cell lung carcinoma in patients with paraneoplastic neuronal antibodies

R B Darnell et al. Lancet. 1993.

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Abstract

We describe three patients with known or suspected small-cell lung cancer (SCLC), paraneoplastic neurological syndromes, and antineuronal antibodies who had unusually benign clinical courses. One patient survived 8 years free of disease and was positive for the anti-Hu antibody. A second patient survived 6 years after spontaneous tumour regression and had an atypical antineuronal antibody. A third patient with both the anti-Hu and atypical antineuronal antibody had spontaneous regression of a lung mass. All three patients had a subacute sensory neuropathy. Since paraneoplastic antineuronal antibodies also bind to tumour cells, these cases suggest that some (paraneoplastic) neurological syndromes without identifiable tumour may result from immune-mediated eradication of tumour cells.

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