Interferon gamma regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells - PubMed (original) (raw)

Interferon gamma regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells

I Iwamoto et al. J Exp Med. 1993.

Abstract

We have previously shown that antigen-induced eosinophil recruitment into the tissue of sensitized mice is mediated by CD4+ T cells and interleukin 5. To determine whether interferon gamma (IFN-gamma) regulates antigen-induced eosinophil recruitment into the tissue, we studied the effect of recombinant (r) murine IFN-gamma and of anti-IFN-gamma monoclonal antibody (mAb) on the eosinophil infiltration of the trachea induced by antigen inhalation in mice. The intraperitoneal administration of rIFN-gamma prevented antigen-induced eosinophil infiltration in the trachea of sensitized mice. The administration of rIFN-gamma also decreased antigen-induced CD4+ T cell but not CD8+ T cell infiltration in the trachea. On the other hand, pretreatment with anti-IFN-gamma mAb enhanced antigen-induced eosinophil and CD4+ T cell infiltration in the trachea. These results indicate that IFN-gamma regulates antigen-induced eosinophil recruitment into the tissue by inhibiting CD4+ T cell infiltration.

PubMed Disclaimer

Similar articles

Cited by

References

    1. J Histochem Cytochem. 1980 Aug;28(8):771-6 - PubMed
    1. J Exp Med. 1984 May 1;159(5):1560-5 - PubMed
    1. J Immunol. 1986 Sep 15;137(6):1893-6 - PubMed
    1. J Immunol. 1988 Feb 15;140(4):1022-7 - PubMed
    1. J Immunol. 1988 Mar 1;140(5):1500-5 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources