Allelic loss of chromosome 1p36 in neuroblastoma is of preferential maternal origin and correlates with N-myc amplification - PubMed (original) (raw)

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Allelic loss of chromosome 1p36 in neuroblastoma is of preferential maternal origin and correlates with N-myc amplification

H Caron et al. Nat Genet. 1993 Jun.

Erratum in

Nat Genet 1993 Aug;4(4):431

Abstract

Neuroblastomas frequently have deletions of chromosome 1p and amplification of the N-myc oncogene. We analysed 53 neuroblastomas for the N-myc copy number, loss of heterozygosity (LOH) of chromosome 1p36 and the parental origin of the lost alleles. Allelic loss of 1p36 was found in 15 tumours. All N-myc amplified tumours belonged to this subset. In 13/15 tumours with LOH of 1p36 the lost allele was of maternal origin. This non-random distribution implies that the two alleles of the putative neuroblastoma suppressor gene on chromosome 1p36 are functionally different, depending on their parental origin. This is the first evidence as far as we know for genomic imprinting on chromosome 1p.

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Comment in

Genomic imprinting and gene activation in cancer.
Feinberg AP. Feinberg AP. Nat Genet. 1993 Jun;4(2):110-3. doi: 10.1038/ng0693-110. Nat Genet. 1993. PMID: 8348145 No abstract available.

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Preferential amplification of the paternal allele of the N-myc gene in human neuroblastomas.
Cheng JM, Hiemstra JL, Schneider SS, Naumova A, Cheung NK, Cohn SL, Diller L, Sapienza C, Brodeur GM. Cheng JM, et al. Nat Genet. 1993 Jun;4(2):191-4. doi: 10.1038/ng0693-191. Nat Genet. 1993. PMID: 8102299

Allelic loss of chromosome 1p36 in neuroblastoma is of preferential maternal origin and correlates with N-myc amplification - PubMed (original) (raw)