The metabotropic glutamate receptor (mGluR1 alpha) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction - PubMed (original) (raw)
The metabotropic glutamate receptor (mGluR1 alpha) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction
A Baude et al. Neuron. 1993 Oct.
Abstract
An antiserum to mGluR1 alpha labeled a 160 kd protein in immunoblots of membranes derived from rat brain or cells transfected with mGluR1 alpha. Immunoreactivity for mGluR1 alpha was present in discrete subpopulations of neurons. The GABAergic neurons of the cerebellar cortex were strongly immunoreactive; only some Golgi cells were immunonegative. Somatostatin/GABA-immunopositive cells in the neocortex and hippocampus were enriched in mGluR1 alpha. The hippocampal cells had spiny dendrites that were precisely codistributed with the local axon collaterals of pyramidal and granule cells. Electron microscopic immunometal detection of mGluR1 alpha showed a preferential localization at the periphery of the extensive postsynaptic densities of type 1 synapses in both the cerebellum and the hippocampus. The receptor was also present at sites in the dendritic and somatic membrane where synapses were not located.
Similar articles
- Characterization of two alternatively spliced forms of a metabotropic glutamate receptor in the central nervous system of the rat.
Hampson DR, Theriault E, Huang XP, Kristensen P, Pickering DS, Franck JE, Mulvihill ER. Hampson DR, et al. Neuroscience. 1994 May;60(2):325-36. doi: 10.1016/0306-4522(94)90246-1. Neuroscience. 1994. PMID: 8072687 - Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1 alpha, mGluR2 and mGluR5, relative to neurotransmitter release sites.
Luján R, Roberts JD, Shigemoto R, Ohishi H, Somogyi P. Luján R, et al. J Chem Neuroanat. 1997 Oct;13(4):219-41. doi: 10.1016/s0891-0618(97)00051-3. J Chem Neuroanat. 1997. PMID: 9412905 - Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampus.
Lujan R, Nusser Z, Roberts JD, Shigemoto R, Somogyi P. Lujan R, et al. Eur J Neurosci. 1996 Jul;8(7):1488-500. doi: 10.1111/j.1460-9568.1996.tb01611.x. Eur J Neurosci. 1996. PMID: 8758956 - High-resolution immunogold localization of AMPA type glutamate receptor subunits at synaptic and non-synaptic sites in rat hippocampus.
Baude A, Nusser Z, Molnár E, McIlhinney RA, Somogyi P. Baude A, et al. Neuroscience. 1995 Dec;69(4):1031-55. doi: 10.1016/0306-4522(95)00350-r. Neuroscience. 1995. PMID: 8848093 - Architecture of the nerve ending membrane.
Smith AP, Loh HH. Smith AP, et al. Life Sci. 1979 Jan 1;24(1):1-20. doi: 10.1016/0024-3205(79)90274-1. Life Sci. 1979. PMID: 216870 Free PMC article. Review. No abstract available.
Cited by
- Amyloid-β Causes NMDA Receptor Dysfunction and Dendritic Spine Loss through mGluR1 and AKAP150-Anchored Calcineurin Signaling.
Prikhodko O, Freund RK, Sullivan E, Kennedy MJ, Dell'Acqua ML. Prikhodko O, et al. J Neurosci. 2024 Sep 11;44(37):e0675242024. doi: 10.1523/JNEUROSCI.0675-24.2024. J Neurosci. 2024. PMID: 39134419 - MC4R Localizes at Excitatory Postsynaptic and Peri-Postsynaptic Sites of Hypothalamic Neurons in Primary Culture.
Griffin H, Hanson J, Phelan KD, Baldini G. Griffin H, et al. Cells. 2024 Jul 23;13(15):1235. doi: 10.3390/cells13151235. Cells. 2024. PMID: 39120267 Free PMC article. - Multiplexed volumetric CLEM enabled by scFvs provides insights into the cytology of cerebellar cortex.
Han X, Lu X, Li PH, Wang S, Schalek R, Meirovitch Y, Lin Z, Adhinarta J, Murray KD, MacNiven LM, Berger DR, Wu Y, Fang T, Meral ES, Asraf S, Ploegh H, Pfister H, Wei D, Jain V, Trimmer JS, Lichtman JW. Han X, et al. Nat Commun. 2024 Aug 5;15(1):6648. doi: 10.1038/s41467-024-50411-z. Nat Commun. 2024. PMID: 39103318 Free PMC article. - Pre- and Postembedding Immunoelectron Microscopy to Analyze the Central Nervous System.
Fujiyama F, Karube F. Fujiyama F, et al. Methods Mol Biol. 2024;2794:45-62. doi: 10.1007/978-1-0716-3810-1_5. Methods Mol Biol. 2024. PMID: 38630219 - Synaptic plasticity at the dentate gyrus granule cell to somatostatin-expressing interneuron synapses supports object location memory.
Grigoryan G, Harada H, Knobloch-Bollmann HS, Kilias A, Kaufhold D, Kulik A, Eyre MD, Bartos M. Grigoryan G, et al. Proc Natl Acad Sci U S A. 2023 Dec 19;120(51):e2312752120. doi: 10.1073/pnas.2312752120. Epub 2023 Dec 13. Proc Natl Acad Sci U S A. 2023. PMID: 38091292 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Miscellaneous