Active propagation of somatic action potentials into neocortical pyramidal cell dendrites - PubMed (original) (raw)
. 1994 Jan 6;367(6458):69-72.
doi: 10.1038/367069a0.
Affiliations
- PMID: 8107777
- DOI: 10.1038/367069a0
Active propagation of somatic action potentials into neocortical pyramidal cell dendrites
G J Stuart et al. Nature. 1994.
Abstract
The dendrites of neurons in the mammalian central nervous system have been considered as electrically passive structures which funnel synaptic potentials to the soma and axon initial segment, the site of action potential initiation. More recent studies, however, have shown that the dendrites of many neurons are not passive, but contain active conductances. The role of these dendritic voltage-activated channels in the initiation of action potentials in neurons is largely unknown. To assess this directly, patch-clamp recordings were made from the dendrites of neocortical pyramidal cells in brain slices. Voltage-activated sodium currents were observed in dendritic outside-out patches, while action potentials could be evoked by depolarizing current pulses or by synaptic stimulation during dendritic whole-cell recordings. To determine the site of initiation of these action potentials, simultaneous whole-cell recordings were made from the soma and the apical dendrite or axon of the same cell. These experiments showed that action potentials are initiated first in the axon and then actively propagate back into the dendritic tree.
Similar articles
- Action potential initiation and propagation in rat neocortical pyramidal neurons.
Stuart G, Schiller J, Sakmann B. Stuart G, et al. J Physiol. 1997 Dec 15;505 ( Pt 3)(Pt 3):617-32. doi: 10.1111/j.1469-7793.1997.617ba.x. J Physiol. 1997. PMID: 9457640 Free PMC article. - Properties of action-potential initiation in neocortical pyramidal cells: evidence from whole cell axon recordings.
Shu Y, Duque A, Yu Y, Haider B, McCormick DA. Shu Y, et al. J Neurophysiol. 2007 Jan;97(1):746-60. doi: 10.1152/jn.00922.2006. Epub 2006 Nov 8. J Neurophysiol. 2007. PMID: 17093120 - Multiple modes of action potential initiation and propagation in mitral cell primary dendrite.
Chen WR, Shen GY, Shepherd GM, Hines ML, Midtgaard J. Chen WR, et al. J Neurophysiol. 2002 Nov;88(5):2755-64. doi: 10.1152/jn.00057.2002. J Neurophysiol. 2002. PMID: 12424310 - Dendritic spikes and activity-dependent synaptic plasticity.
Holthoff K, Kovalchuk Y, Konnerth A. Holthoff K, et al. Cell Tissue Res. 2006 Nov;326(2):369-77. doi: 10.1007/s00441-006-0263-8. Epub 2006 Jul 1. Cell Tissue Res. 2006. PMID: 16816965 Review. - How voltage-gated ion channels alter the functional properties of ganglion and amacrine cell dendrites.
Miller RF, Stenback K, Henderson D, Sikora M. Miller RF, et al. Arch Ital Biol. 2002 Oct;140(4):347-59. Arch Ital Biol. 2002. PMID: 12228988 Review.
Cited by
- Cl--dependent amplification of excitatory synaptic potentials at distal dendrites revealed by voltage imaging.
Higashi R, Morita M, Kawaguchi SY. Higashi R, et al. Sci Adv. 2024 Aug 30;10(35):eadj2547. doi: 10.1126/sciadv.adj2547. Epub 2024 Aug 28. Sci Adv. 2024. PMID: 39196927 Free PMC article. - Optimization of an anatomically and electrically detailed rodent subthalamic nucleus neuron model.
Chen H, Noor MS, Bingham CS, McIntyre CC. Chen H, et al. J Neurophysiol. 2024 Jul 1;132(1):136-146. doi: 10.1152/jn.00287.2023. Epub 2024 Jun 12. J Neurophysiol. 2024. PMID: 38863430 Free PMC article. - Functional Dynamics and Selectivity of Two Parallel Corticocortical Pathways from Motor Cortex to Layer 5 Circuits in Somatosensory Cortex.
Kim HH, Bonekamp KE, Gillie GR, Autio DM, Keller T, Crandall SR. Kim HH, et al. eNeuro. 2024 Jun 21;11(6):ENEURO.0154-24.2024. doi: 10.1523/ENEURO.0154-24.2024. Print 2024 Jun. eNeuro. 2024. PMID: 38834298 Free PMC article. - Kinetics and functional consequences of BK channels activation by N-type Ca2+ channels in the dendrite of mouse neocortical layer-5 pyramidal neurons.
Blömer LA, Giacalone E, Abbas F, Filipis L, Tegolo D, Migliore M, Canepari M. Blömer LA, et al. Front Cell Neurosci. 2024 Feb 14;18:1353895. doi: 10.3389/fncel.2024.1353895. eCollection 2024. Front Cell Neurosci. 2024. PMID: 38419657 Free PMC article. - Functional dynamics and selectivity of two parallel corticocortical pathways from motor cortex to layer 5 circuits in somatosensory cortex.
Kim HH, Bonekamp KE, Gillie GR, Autio DM, Keller T, Crandall SR. Kim HH, et al. bioRxiv [Preprint]. 2024 May 20:2024.02.11.579810. doi: 10.1101/2024.02.11.579810. bioRxiv. 2024. PMID: 38405888 Free PMC article. Updated. Preprint.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources