Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits - PubMed (original) (raw)
. 1994 Feb 3;367(6462):463-7.
doi: 10.1038/367463a0.
Affiliations
- PMID: 8107805
- DOI: 10.1038/367463a0
Free article
Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits
C M Canessa et al. Nature. 1994.
Free article
Abstract
The amiloride-sensitive epithelial sodium channel constitutes the rate-limiting step for sodium reabsorption in epithelial cells that line the distal part of the renal tubule, the distal colon, the duct of several exocrine glands, and the lung. The activity of this channel is upregulated by vasopressin and aldosterone, hormones involved in the maintenance of sodium balance, blood volume and blood pressure. We have identified the primary structure of the alpha-subunit of the rat epithelial sodium channel by expression cloning in Xenopus laevis oocytes. An identical subunit has recently been reported. Here we identify two other subunits (beta and gamma) by functional complementation of the alpha-subunit of the rat epithelial Na+ channel. The ion-selective permeability, the gating properties and the pharmacological profile of the channel formed by coexpressing the three subunits in oocytes are similar to that of the native channel.
Comment in
- Trinity of cation channels.
Jentsch TJ. Jentsch TJ. Nature. 1994 Feb 3;367(6462):412-3. doi: 10.1038/367412a0. Nature. 1994. PMID: 7509038 No abstract available.
Similar articles
- Epithelial sodium channel related to proteins involved in neurodegeneration.
Canessa CM, Horisberger JD, Rossier BC. Canessa CM, et al. Nature. 1993 Feb 4;361(6411):467-70. doi: 10.1038/361467a0. Nature. 1993. PMID: 8381523 - A mutation causing pseudohypoaldosteronism type 1 identifies a conserved glycine that is involved in the gating of the epithelial sodium channel.
Gründer S, Firsov D, Chang SS, Jaeger NF, Gautschi I, Schild L, Lifton RP, Rossier BC. Gründer S, et al. EMBO J. 1997 Mar 3;16(5):899-907. doi: 10.1093/emboj/16.5.899. EMBO J. 1997. PMID: 9118951 Free PMC article. - Stimulation of epithelial sodium channel activity by the sulfonylurea glibenclamide.
Chrabi A, Horisberger JD. Chrabi A, et al. J Pharmacol Exp Ther. 1999 Jul;290(1):341-7. J Pharmacol Exp Ther. 1999. PMID: 10381797 - [Distribution of amiloride-sensitive sodium channel in epithelial tissue].
Bonvalet JP, Rossier B, Farman N. Bonvalet JP, et al. C R Seances Soc Biol Fil. 1995;189(2):169-77. C R Seances Soc Biol Fil. 1995. PMID: 8590216 Review. French. - [The amiloride sensitive sodium channel].
Barbry P, Champigny G, Lingueglia E, Voilley N, Waldmann R, Lazdunski M. Barbry P, et al. Nephrologie. 1996;17(7):389-93. Nephrologie. 1996. PMID: 9019666 Review. French.
Cited by
- Cystic Fibrosis: A Journey through Time and Hope.
Trouvé P, Saint Pierre A, Férec C. Trouvé P, et al. Int J Mol Sci. 2024 Sep 4;25(17):9599. doi: 10.3390/ijms25179599. Int J Mol Sci. 2024. PMID: 39273547 Free PMC article. Review. - A Possible Link between Cell Plasticity and Renin Expression in the Collecting Duct: A Narrative Review.
Schary N, Edemir B, Todorov VT. Schary N, et al. Int J Mol Sci. 2024 Sep 3;25(17):9549. doi: 10.3390/ijms25179549. Int J Mol Sci. 2024. PMID: 39273497 Free PMC article. Review. - The epithelial Na+ channel (ENaC) in ovarian granulosa cells modulates Ca2+ mobilization and gonadotrophin signaling for estrogen homeostasis and female fertility.
Ma X, Xu R, Chen J, Wang S, Hu P, Wu Y, Que Y, Du W, Cai X, Chen H, Guo J, Li TC, Ruan YC. Ma X, et al. Cell Commun Signal. 2024 Aug 14;22(1):398. doi: 10.1186/s12964-024-01778-5. Cell Commun Signal. 2024. PMID: 39143495 Free PMC article. - Epithelial Na + Channels Function as Extracellular Sensors.
Kashlan OB, Wang XP, Sheng S, Kleyman TR. Kashlan OB, et al. Compr Physiol. 2024 Mar 29;14(2):1-41. doi: 10.1002/cphy.c230015. Compr Physiol. 2024. PMID: 39109974 Review. - Varying Selection Pressure for a Na+ Sensing Site in Epithelial Na+ Channel Subunits Reflect Divergent Roles in Na+ Homeostasis.
Wang XP, Srinivasan P, El Hamdaoui M, Blobner BM, Grytz R, Kashlan OB. Wang XP, et al. Mol Biol Evol. 2024 Aug 2;41(8):msae162. doi: 10.1093/molbev/msae162. Mol Biol Evol. 2024. PMID: 39101592 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases