Role for poliovirus protease 2A in cap independent translation - PubMed (original) (raw)
Role for poliovirus protease 2A in cap independent translation
A J Macadam et al. EMBO J. 1994.
Abstract
Viral protein synthesis in poliovirus infected cells was found to be influenced by mutations in part of the viral 5'-non-coding region (NCR) in a temperature dependent manner. At elevated temperatures these mutations resulted in virus titre reductions that allowed selection of revertant viruses. Some revertants were found to have retained the 5'-NCR mutations but had compensating mutations in the 2A protease gene that were responsible for the suppression of the temperature sensitive phenotypes. The mutations in 2A enhanced viral protein synthesis at a stage when cap dependent translation was already abolished, suggesting that the virally encoded protein 2A is directly involved in the process of cap independent translation in addition to its role in abolishing cap dependent translation.
Similar articles
- The C-terminal residues of poliovirus proteinase 2A(pro) are critical for viral RNA replication but not for cis- or trans-proteolytic cleavage.
Li X, Lu HH, Mueller S, Wimmer E. Li X, et al. J Gen Virol. 2001 Feb;82(Pt 2):397-408. doi: 10.1099/0022-1317-82-2-397. J Gen Virol. 2001. PMID: 11161279 - A poliovirus 2A(pro) mutant unable to cleave 3CD shows inefficient viral protein synthesis and transactivation defects.
Ventoso I, Carrasco L. Ventoso I, et al. J Virol. 1995 Oct;69(10):6280-8. doi: 10.1128/JVI.69.10.6280-6288.1995. J Virol. 1995. PMID: 7666528 Free PMC article. - Identification of essential amino acid residues in the functional activity of poliovirus 2A protease.
Yu SF, Lloyd RE. Yu SF, et al. Virology. 1991 Jun;182(2):615-25. doi: 10.1016/0042-6822(91)90602-8. Virology. 1991. PMID: 1850921 - A poliovirus minireplicon containing an inactive 2A proteinase is expressed in vaccinia virus-infected cells.
Pal-Ghosh R, Morrow CD. Pal-Ghosh R, et al. J Virol. 1993 Aug;67(8):4621-9. doi: 10.1128/JVI.67.8.4621-4629.1993. J Virol. 1993. PMID: 8392603 Free PMC article. - IRES-controlled protein synthesis and genome replication of poliovirus.
Schmid M, Wimmer E. Schmid M, et al. Arch Virol Suppl. 1994;9:279-89. doi: 10.1007/978-3-7091-9326-6_28. Arch Virol Suppl. 1994. PMID: 8032259 Review.
Cited by
- Viral cysteine proteinases.
Gorbalenya AE, Snijder EJ. Gorbalenya AE, et al. Perspect Drug Discov Des. 1996;6(1):64-86. doi: 10.1007/BF02174046. Perspect Drug Discov Des. 1996. PMID: 32288276 Free PMC article. - Nucleotide variation in Sabin type 3 poliovirus from an Albanian infant with agammaglobulinemia and vaccine associated poliomyelitis.
Foiadelli T, Savasta S, Battistone A, Kota M, Passera C, Fiore S, Bino S, Amato C, Lozza A, Marseglia GL, Fiore L. Foiadelli T, et al. BMC Infect Dis. 2016 Jun 10;16:277. doi: 10.1186/s12879-016-1587-y. BMC Infect Dis. 2016. PMID: 27287521 Free PMC article. - Translation without eIF2 promoted by poliovirus 2A protease.
Redondo N, Sanz MA, Welnowska E, Carrasco L. Redondo N, et al. PLoS One. 2011;6(10):e25699. doi: 10.1371/journal.pone.0025699. Epub 2011 Oct 7. PLoS One. 2011. PMID: 22003403 Free PMC article. - The porcine reproductive and respiratory syndrome virus nsp2 cysteine protease domain possesses both trans- and cis-cleavage activities.
Han J, Rutherford MS, Faaberg KS. Han J, et al. J Virol. 2009 Sep;83(18):9449-63. doi: 10.1128/JVI.00834-09. Epub 2009 Jul 8. J Virol. 2009. PMID: 19587037 Free PMC article. - Changes in population dynamics during long-term evolution of sabin type 1 poliovirus in an immunodeficient patient.
Odoom JK, Yunus Z, Dunn G, Minor PD, Martín J. Odoom JK, et al. J Virol. 2008 Sep;82(18):9179-90. doi: 10.1128/JVI.00468-08. Epub 2008 Jul 2. J Virol. 2008. PMID: 18596089 Free PMC article.
References
- Proc Natl Acad Sci U S A. 1986 Apr;83(8):2330-4 - PubMed
- J Gen Virol. 1992 Dec;73 ( Pt 12):3065-77 - PubMed
- J Biol Chem. 1987 Aug 15;262(23):11134-9 - PubMed
- J Gen Virol. 1988 May;69 ( Pt 5):1091-6 - PubMed
- Nature. 1988 Jul 28;334(6180):320-5 - PubMed
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous