Functional versus quantitative comparison of IL-1 beta from monocytes/macrophages on biomedical polymers - PubMed (original) (raw)
Comparative Study
Functional versus quantitative comparison of IL-1 beta from monocytes/macrophages on biomedical polymers
T L Bonfield et al. J Biomed Mater Res. 1993 Sep.
Erratum in
- J Biomed Mater Res 1994 Jan;28(1);137
Abstract
Studies utilizing a quantitative assay, radioimmunoassay, and a biological activity assay, the murine thymocyte proliferation assay, to analyze IL-1 beta cytokine production by monocytes/macrophages on biomedical polymers have been carried out. Results indicate that the quantitative analysis of IL-1 beta on biomedical polymers and protein-adsorbed biomedical polymers is not indicative of and does not correlate with the results of the biological activity assay. IL-1 beta secreted from human monocytes/macrophages on Biomer, polydimethylsiloxane (PDMS), Dacron, polyethylene, expanded polytetrafluoroethylene, and control polystyrene with and without the preadsorption of physiological concentrations of human IgG, fibrinogen, and/or fibronectin was assayed. Quantitative levels of IL-1 beta suggest a greater functional response than that observed in the biological thymocyte proliferation assay when the polymers were studied directly or preadsorbed with IgG. On the other hand, preadsorption with fibrinogen or fibronectin resulted in high functional activity for IL-1 beta with low quantitative levels of IL-1 beta. The lack of correlation between the functional and biological activity assays suggests the presence of other cytokines or antagonists which modulate the biological activity of IL-1 beta.
Similar articles
- Cytokine and growth factor production by monocytes/macrophages on protein preadsorbed polymers.
Bonfield TL, Colton E, Marchant RE, Anderson JM. Bonfield TL, et al. J Biomed Mater Res. 1992 Jul;26(7):837-50. doi: 10.1002/jbm.820260702. J Biomed Mater Res. 1992. PMID: 1607370 - Human monocyte/macrophage adhesion and cytokine production on surface-modified poly(tetrafluoroethylene/hexafluoropropylene) polymers with and without protein preadsorption.
Yun JK, DeFife K, Colton E, Stack S, Azeez A, Cahalan L, Verhoeven M, Cahalan P, Anderson JM. Yun JK, et al. J Biomed Mater Res. 1995 Feb;29(2):257-68. doi: 10.1002/jbm.820290217. J Biomed Mater Res. 1995. PMID: 7738074 - Protein adsorption of biomedical polymers influences activated monocytes to produce fibroblast stimulating factors.
Bonfield TL, Colton E, Anderson JM. Bonfield TL, et al. J Biomed Mater Res. 1992 Apr;26(4):457-65. doi: 10.1002/jbm.820260404. J Biomed Mater Res. 1992. PMID: 1601899 - Human monocyte/macrophage activation and interleukin 1 generation by biomedical polymers.
Miller KM, Anderson JM. Miller KM, et al. J Biomed Mater Res. 1988 Aug;22(8):713-31. doi: 10.1002/jbm.820220805. J Biomed Mater Res. 1988. PMID: 3265135 - In vitro stimulation of fibroblast activity by factors generated from human monocytes activated by biomedical polymers.
Miller KM, Anderson JM. Miller KM, et al. J Biomed Mater Res. 1989 Aug;23(8):911-30. doi: 10.1002/jbm.820230808. J Biomed Mater Res. 1989. PMID: 2528547
Cited by
- Biocompatibility and Effectiveness Evaluation of a New Hemostatic Embolization Agent: Thrombin Loaded Alginate Calcium Microsphere.
Xuan F, Rong J, Liang M, Zhang X, Sun J, Zhao L, Li Y, Liu D, Li F, Wang X, Han Y. Xuan F, et al. Biomed Res Int. 2017;2017:1875258. doi: 10.1155/2017/1875258. Epub 2017 Feb 16. Biomed Res Int. 2017. PMID: 28303245 Free PMC article. - Future challenges in the in vitro and in vivo evaluation of biomaterial biocompatibility.
Anderson JM. Anderson JM. Regen Biomater. 2016 Jun;3(2):73-7. doi: 10.1093/rb/rbw001. Epub 2016 Mar 10. Regen Biomater. 2016. PMID: 27047672 Free PMC article. Review. - Biomaterial topography alters healing in vivo and monocyte/macrophage activation in vitro.
Bota PC, Collie AM, Puolakkainen P, Vernon RB, Sage EH, Ratner BD, Stayton PS. Bota PC, et al. J Biomed Mater Res A. 2010 Nov;95(2):649-57. doi: 10.1002/jbm.a.32893. J Biomed Mater Res A. 2010. PMID: 20725970 Free PMC article. - Foreign body reaction to biomaterials.
Anderson JM, Rodriguez A, Chang DT. Anderson JM, et al. Semin Immunol. 2008 Apr;20(2):86-100. doi: 10.1016/j.smim.2007.11.004. Epub 2007 Dec 26. Semin Immunol. 2008. PMID: 18162407 Free PMC article. Review. - Brain lesion-induced alteration of selected phenotypic properties of spleen macrophages and their partial restoration in the course of foreign body reaction against intraperitoneally implanted polymers.
Smetana K Jr, Petrovický P, Zach P, Nemcová V, Jelínková M, Vacík J, Gabius HJ. Smetana K Jr, et al. J Mater Sci Mater Med. 1999 Jul;10(7):425-9. doi: 10.1023/a:1008931231762. J Mater Sci Mater Med. 1999. PMID: 15348128
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources