Expression and localization of amiloride-sensitive sodium channel indicate a role for non-taste cells in taste perception - PubMed (original) (raw)
Expression and localization of amiloride-sensitive sodium channel indicate a role for non-taste cells in taste perception
X J Li et al. Proc Natl Acad Sci U S A. 1994.
Abstract
Salty taste is blocked by the diuretic amiloride, which inhibits specific sodium channels. We have isolated an amiloride-sensitive sodium channel (ASSC) from taste tissues by polymerase chain reaction and screening of a cDNA library prepared from rat circumvallate papillae. Northern analysis reveals ASSC in taste and non-taste tissues with the highest level of expression of ASSC in the lung. In situ hybridization establishes ASSC localizations in the epithelia of lung and colon as well as tongue epithelial layers containing and lacking taste buds. These results support a model in which ASSC in non-taste cells regulates responses of taste cells to salt as well as other tastants.
Similar articles
- Distribution and characterization of functional amiloride-sensitive sodium channels in rat tongue.
Doolin RE, Gilbertson TA. Doolin RE, et al. J Gen Physiol. 1996 Apr;107(4):545-54. doi: 10.1085/jgp.107.4.545. J Gen Physiol. 1996. PMID: 8722566 Free PMC article. - Self-inhibition in amiloride-sensitive sodium channels in taste receptor cells.
Gilbertson TA, Zhang H. Gilbertson TA, et al. J Gen Physiol. 1998 May;111(5):667-77. doi: 10.1085/jgp.111.5.667. J Gen Physiol. 1998. PMID: 9565404 Free PMC article. - Differential expression of RNA and protein of the three pore-forming subunits of the amiloride-sensitive epithelial sodium channel in taste buds of the rat.
Kretz O, Barbry P, Bock R, Lindemann B. Kretz O, et al. J Histochem Cytochem. 1999 Jan;47(1):51-64. doi: 10.1177/002215549904700106. J Histochem Cytochem. 1999. PMID: 9857212 - [Distribution of amiloride-sensitive sodium channel in epithelial tissue].
Bonvalet JP, Rossier B, Farman N. Bonvalet JP, et al. C R Seances Soc Biol Fil. 1995;189(2):169-77. C R Seances Soc Biol Fil. 1995. PMID: 8590216 Review. French. - Identification of sour-taste receptor genes.
Ugawa S. Ugawa S. Anat Sci Int. 2003 Dec;78(4):205-10. doi: 10.1046/j.0022-7722.2003.00062.x. Anat Sci Int. 2003. PMID: 14686475 Review.
Cited by
- Two-generation exposure to a high-fat diet induces the change of salty taste preference in rats.
Serirukchutarungsee S, Watari I, Narukawa M, Podyma-Inoue KA, Sangsuriyothai P, Ono T. Serirukchutarungsee S, et al. Sci Rep. 2023 Apr 7;13(1):5742. doi: 10.1038/s41598-023-31662-0. Sci Rep. 2023. PMID: 37029190 Free PMC article. - Does ENaC Work as Sodium Taste Receptor in Humans?
Bigiani A. Bigiani A. Nutrients. 2020 Apr 24;12(4):1195. doi: 10.3390/nu12041195. Nutrients. 2020. PMID: 32344597 Free PMC article. Review. - Pragmatically on the sense of taste - a short treatise based on culinary art.
Waluga M, Jonderko K, Buschhaus M. Waluga M, et al. Prz Gastroenterol. 2013;8(6):338-44. doi: 10.5114/pg.2013.39915. Epub 2013 Dec 30. Prz Gastroenterol. 2013. PMID: 24868281 Free PMC article. Review. - Genetics of taste receptors.
Bachmanov AA, Bosak NP, Lin C, Matsumoto I, Ohmoto M, Reed DR, Nelson TM. Bachmanov AA, et al. Curr Pharm Des. 2014;20(16):2669-83. doi: 10.2174/13816128113199990566. Curr Pharm Des. 2014. PMID: 23886383 Free PMC article. Review. - Amiloride-sensitive channels in type I fungiform taste cells in mouse.
Vandenbeuch A, Clapp TR, Kinnamon SC. Vandenbeuch A, et al. BMC Neurosci. 2008 Jan 2;9:1. doi: 10.1186/1471-2202-9-1. BMC Neurosci. 2008. PMID: 18171468 Free PMC article.
References
- N Engl J Med. 1990 Apr 26;322(17):1189-94 - PubMed
- J Cell Sci. 1989 Jun;93 ( Pt 2):349-62 - PubMed
- Proc Natl Acad Sci U S A. 1990 Oct;87(19):7347-51 - PubMed
- Proc Natl Acad Sci U S A. 1990 Oct;87(19):7395-9 - PubMed
- Brain Res. 1991 Feb 8;541(1):21-8 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources