Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins - PubMed (original) (raw)
. 1994 Apr 1;269(13):9889-97.
Affiliations
- PMID: 8144582
Free article
Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins
S D Yan et al. J Biol Chem. 1994.
Free article
Abstract
Attack by reactive oxygen intermediates, common to many kinds of cell/tissue injury, has been implicated in the development of diabetic and other vascular diseases. Such oxygen-free radicals can be generated by advanced glycation end products (AGEs), which are nonenzymatically glycated and oxidized proteins. Since cellular interactions of AGEs are mediated by specific cellular binding proteins, receptor for AGE (RAGE) and the lactoferrin-like polypeptide (LF-L), we tested the hypothesis that AGE ligands tethered to the complex of RAGE and LF-L could induce oxidant stress. AGE albumin or AGEs immunoisolated from diabetic plasma resulted in induction of endothelial cell (EC) oxidant stress, including the generation of thiobarbituric acid reactive substances (TBARS) and resulted in the activation of NF-kappa B, each of which was blocked by antibodies to AGE receptor polypeptides and by antioxidants. Infusion of AGE albumin into normal animals led to the appearance of malondialdehyde determinants in the vessel wall and increased TBARS in the tissues, activation of NF-kappa B, and induction of heme oxygenase mRNA. AGE-induced oxidant stress was inhibited by pretreatment of animals with either antibodies to the AGE receptor/binding proteins or antioxidants. These data indicate that interaction of AGEs with cellular targets, such as ECs, leads to oxidant stress resulting in changes in gene expression and other cellular properties, potentially contributing to the development of vascular lesions. Further studies will be required to dissect whether oxidant stress occurs on the cell surface or at an intracellular locus.
Similar articles
- Advanced glycation end products (AGEs) on the surface of diabetic erythrocytes bind to the vessel wall via a specific receptor inducing oxidant stress in the vasculature: a link between surface-associated AGEs and diabetic complications.
Wautier JL, Wautier MP, Schmidt AM, Anderson GM, Hori O, Zoukourian C, Capron L, Chappey O, Yan SD, Brett J, et al. Wautier JL, et al. Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7742-6. doi: 10.1073/pnas.91.16.7742. Proc Natl Acad Sci U S A. 1994. PMID: 8052654 Free PMC article. - RAGE: a novel cellular receptor for advanced glycation end products.
Schmidt AM, Hori O, Cao R, Yan SD, Brett J, Wautier JL, Ogawa S, Kuwabara K, Matsumoto M, Stern D. Schmidt AM, et al. Diabetes. 1996 Jul;45 Suppl 3:S77-80. doi: 10.2337/diab.45.3.s77. Diabetes. 1996. PMID: 8674899 Review. - The endothelial cell binding site for advanced glycation end products consists of a complex: an integral membrane protein and a lactoferrin-like polypeptide.
Schmidt AM, Mora R, Cao R, Yan SD, Brett J, Ramakrishnan R, Tsang TC, Simionescu M, Stern D. Schmidt AM, et al. J Biol Chem. 1994 Apr 1;269(13):9882-8. J Biol Chem. 1994. PMID: 8144581 - Advanced glycation endproducts (AGEs) induce oxidant stress in the gingiva: a potential mechanism underlying accelerated periodontal disease associated with diabetes.
Schmidt AM, Weidman E, Lalla E, Yan SD, Hori O, Cao R, Brett JG, Lamster IB. Schmidt AM, et al. J Periodontal Res. 1996 Oct;31(7):508-15. doi: 10.1111/j.1600-0765.1996.tb01417.x. J Periodontal Res. 1996. PMID: 8915955 - Cellular receptors for advanced glycation end products. Implications for induction of oxidant stress and cellular dysfunction in the pathogenesis of vascular lesions.
Schmidt AM, Hori O, Brett J, Yan SD, Wautier JL, Stern D. Schmidt AM, et al. Arterioscler Thromb. 1994 Oct;14(10):1521-8. doi: 10.1161/01.atv.14.10.1521. Arterioscler Thromb. 1994. PMID: 7918300 Review.
Cited by
- Effect of Different Glucose Levels and Glycation on Meningioma Cell Migration and Invasion.
Selke P, Strauss C, Horstkorte R, Scheer M. Selke P, et al. Int J Mol Sci. 2024 Sep 19;25(18):10075. doi: 10.3390/ijms251810075. Int J Mol Sci. 2024. PMID: 39337558 Free PMC article. - Association between endothelial function and skin advanced glycation end-products (AGEs) accumulation in a sample of predominantly young and healthy adults.
Fewkes JJ, Dordevic AL, Murray M, Williamson G, Kellow NJ. Fewkes JJ, et al. Cardiovasc Diabetol. 2024 Sep 9;23(1):332. doi: 10.1186/s12933-024-02428-3. Cardiovasc Diabetol. 2024. PMID: 39251982 Free PMC article. - Advanced Glycation End-Products Acting as Immunomodulators for Chronic Inflammation, Inflammaging and Carcinogenesis in Patients with Diabetes and Immune-Related Diseases.
Shen CY, Lu CH, Cheng CF, Li KJ, Kuo YM, Wu CH, Liu CH, Hsieh SC, Tsai CY, Yu CL. Shen CY, et al. Biomedicines. 2024 Jul 31;12(8):1699. doi: 10.3390/biomedicines12081699. Biomedicines. 2024. PMID: 39200164 Free PMC article. Review. - Therapeutic strategies targeting mechanisms of macrophages in diabetic heart disease.
Zhang C, Shi Y, Liu C, Sudesh SM, Hu Z, Li P, Liu Q, Ma Y, Shi A, Cai H. Zhang C, et al. Cardiovasc Diabetol. 2024 May 15;23(1):169. doi: 10.1186/s12933-024-02273-4. Cardiovasc Diabetol. 2024. PMID: 38750502 Free PMC article. Review. - Oxidative Stress, Endothelial Dysfunction, and _N_-Acetylcysteine in Type 2 Diabetes Mellitus.
Li X, Zou J, Lin A, Chi J, Hao H, Chen H, Liu Z. Li X, et al. Antioxid Redox Signal. 2024 Jun;40(16-18):968-989. doi: 10.1089/ars.2023.0524. Epub 2024 Apr 29. Antioxid Redox Signal. 2024. PMID: 38497734 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources