Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases - PubMed (original) (raw)
. 1994 Mar 15;152(6):3183-8.
Affiliations
- PMID: 8144912
Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases
D U Rabin et al. J Immunol. 1994.
Abstract
Islet cell Ag 512 (ICA512) is a recombinant human Ag that was isolated from an islet cDNA expression library by screening with human insulin-dependent diabetes mellitus sera. Specificity of reaction with diabetic sera was demonstrated initially by immunoprecipitation with a small number of diabetic and normal serum samples. To permit quantitative and rapid serum testing, ICA512 was purified and adapted to an ELISA format. In this way, a sensitivity of 48% with newly diagnosed diabetic sera has been measured with a panel of 80 sera. DNA sequencing of ICA512-3, a cDNA that contains a 1644 bp open reading frame, suggests that it codes for a transmembrane protein having a single membrane-spanning segment and a cytoplasmic domain that is closely related to the first intracellular (catalytic) domain of the T cell protein tyrosine phosphatase, CD45. Northern blot analysis of poly(A)+ RNAs from several human tissues indicates that ICA512 mRNA is expressed in brain and pancreas.
Similar articles
- Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetes.
Kawasaki E, Hutton JC, Eisenbarth GS. Kawasaki E, et al. Biochem Biophys Res Commun. 1996 Oct 14;227(2):440-7. doi: 10.1006/bbrc.1996.1526. Biochem Biophys Res Commun. 1996. PMID: 8878534 - Autoantigens in insulin-dependent diabetes mellitus: molecular cloning and characterization of human IA-2 beta.
Li Q, Borovitskaya AE, DeSilva MG, Wasserfall C, Maclaren NK, Notkins AL, Lan MS. Li Q, et al. Proc Assoc Am Physicians. 1997 Jul;109(4):429-39. Proc Assoc Am Physicians. 1997. PMID: 9220540 Clinical Trial. - An islet-cell protein tyrosine phosphatase is a likely precursor to the 37-kDa autoantigen in type 1 diabetes: human and macaque sequences, tissue distribution, unique and shared epitopes, and predictive autoantibodies.
LaGasse J, Jelinek L, Sexson S, Lofton-Day C, Breininger J, Sheppard P, Kindsvogel W, Hagopian WA. LaGasse J, et al. Mol Med. 1997 Mar;3(3):163-73. Mol Med. 1997. PMID: 9100223 Free PMC article. - Relation between cellular and humoral immunity to islet cell antigens in type 1 diabetes.
Hummel M, Durinovic-Bello I, Ziegler AG. Hummel M, et al. J Autoimmun. 1996 Jun;9(3):427-30. doi: 10.1006/jaut.1996.0059. J Autoimmun. 1996. PMID: 8816982 - Controversial topics series: milk proteins and diabetes.
Norris JM, Pietropaolo M. Norris JM, et al. J Endocrinol Invest. 1999 Jul-Aug;22(7):568-80. doi: 10.1007/BF03343611. J Endocrinol Invest. 1999. PMID: 10475157 Review. No abstract available.
Cited by
- Antigen presentation: lysoyme, autoimmune diabetes, and Listeria--what do they have in common?
Unanue E, Byersdorfer C, Carrero J, Levisetti M, Lovitch S, Pu Z, Suri A. Unanue E, et al. Immunol Res. 2005;32(1-3):267-92. doi: 10.1385/IR:32:1-3:267. Immunol Res. 2005. PMID: 16106079 Review. - Autoimmune polyglandular syndrome Type 2: the tip of an iceberg?
Betterle C, Lazzarotto F, Presotto F. Betterle C, et al. Clin Exp Immunol. 2004 Aug;137(2):225-33. doi: 10.1111/j.1365-2249.2004.02561.x. Clin Exp Immunol. 2004. PMID: 15270837 Free PMC article. Review. - Distinct clinical and laboratory characteristics of latent autoimmune diabetes in adults in relation to type 1 and type 2 diabetes mellitus.
Pipi E, Marketou M, Tsirogianni A. Pipi E, et al. World J Diabetes. 2014 Aug 15;5(4):505-10. doi: 10.4239/wjd.v5.i4.505. World J Diabetes. 2014. PMID: 25126396 Free PMC article. Review. - Critical roles of CD30/CD30L interactions in murine autoimmune diabetes.
Chakrabarty S, Nagata M, Yasuda H, Wen L, Nakayama M, Chowdhury SA, Yamada K, Jin Z, Kotani R, Moriyama H, Shimozato O, Yagita H, Yokono K. Chakrabarty S, et al. Clin Exp Immunol. 2003 Sep;133(3):318-25. doi: 10.1046/j.1365-2249.2003.02223.x. Clin Exp Immunol. 2003. PMID: 12930356 Free PMC article. - Expression, characterization, processing and immunogenicity of an insulin-dependent diabetes mellitus autoantigen, IA-2, in Sf-9 cells.
Xie H, Deng YJ, Notkins AL, Lan MS. Xie H, et al. Clin Exp Immunol. 1998 Sep;113(3):367-72. doi: 10.1046/j.1365-2249.1998.00676.x. Clin Exp Immunol. 1998. PMID: 9737664 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Medical
Molecular Biology Databases
Research Materials
Miscellaneous