Requirement for the yeast gene LON in intramitochondrial proteolysis and maintenance of respiration - PubMed (original) (raw)

. 1994 Apr 8;264(5156):273-6.

doi: 10.1126/science.8146662.

Affiliations

• PMID: 8146662
• DOI: 10.1126/science.8146662

Requirement for the yeast gene LON in intramitochondrial proteolysis and maintenance of respiration

C K Suzuki et al. Science. 1994.

Erratum in

• Requirement for the yeast gene LON in intramitochondrial proteolysis and maintenance of respiration.
  Suzuki CK, Suda K, Wang N, Schatz G. Suzuki CK, et al. Science. 1994 May 13;264(5161):891. doi: 10.1126/science.8178144. Science. 1994. PMID: 8178144 No abstract available.

Abstract

The role of protein degradation in mitochondrial homeostasis was explored by cloning of a gene from Saccharomyces cerevisiae that encodes a protein resembling the adenosine triphosphate (ATP)-dependent bacterial protease Lon. The predicted yeast protein has a typical mitochondrial matrix-targeting sequence at its amino terminus. Yeast cells lacking a functional LON gene contained a nonfunctional mitochondrial genome, were respiratory-deficient, and lacked an ATP-dependent proteolytic activity present in the mitochondria of Lon+ cells. Lon- cells were also impaired in their ability to catalyze the energy-dependent degradation of several mitochondrial matrix proteins and they accumulated electron-dense inclusions in their mitochondrial matrix.

PubMed Disclaimer

Similar articles

• Maize contains a Lon protease gene that can partially complement a yeast pim1-deletion mutant.
  Barakat S, Pearce DA, Sherman F, Rapp WD. Barakat S, et al. Plant Mol Biol. 1998 May;37(1):141-54. doi: 10.1023/a:1005912831051. Plant Mol Biol. 1998. PMID: 9620272
• Promotion of mitochondrial membrane complex assembly by a proteolytically inactive yeast Lon.
  Rep M, van Dijl JM, Suda K, Schatz G, Grivell LA, Suzuki CK. Rep M, et al. Science. 1996 Oct 4;274(5284):103-6. doi: 10.1126/science.274.5284.103. Science. 1996. PMID: 8810243
• Requirement for the yeast gene LON in intramitochondrial proteolysis and maintenance of respiration.
  Suzuki CK, Suda K, Wang N, Schatz G. Suzuki CK, et al. Science. 1994 May 13;264(5161):891. doi: 10.1126/science.8178144. Science. 1994. PMID: 8178144 No abstract available.
• ATP-dependent proteases controlling mitochondrial function in the yeast Saccharomyces cerevisiae.
  Van Dyck L, Langer T. Van Dyck L, et al. Cell Mol Life Sci. 1999 Nov 30;56(9-10):825-42. doi: 10.1007/s000180050029. Cell Mol Life Sci. 1999. PMID: 11212342 Free PMC article. Review.
• ATP-dependent proteases that also chaperone protein biogenesis.
  Suzuki CK, Rep M, van Dijl JM, Suda K, Grivell LA, Schatz G. Suzuki CK, et al. Trends Biochem Sci. 1997 Apr;22(4):118-23. doi: 10.1016/s0968-0004(97)01020-7. Trends Biochem Sci. 1997. PMID: 9149530 Review.

Cited by

• Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM).
  Matsushima Y, Goto Y, Kaguni LS. Matsushima Y, et al. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18410-5. doi: 10.1073/pnas.1008924107. Epub 2010 Oct 7. Proc Natl Acad Sci U S A. 2010. PMID: 20930118 Free PMC article.
• Active-site-directed chemical tools for profiling mitochondrial Lon protease.
  Fishovitz J, Li M, Frase H, Hudak J, Craig S, Ko K, Berdis AJ, Suzuki CK, Lee I. Fishovitz J, et al. ACS Chem Biol. 2011 Aug 19;6(8):781-8. doi: 10.1021/cb100408w. Epub 2011 May 6. ACS Chem Biol. 2011. PMID: 21520912 Free PMC article.
• The ATP-dependent PIM1 protease is required for the expression of intron-containing genes in mitochondria.
  van Dyck L, Neupert W, Langer T. van Dyck L, et al. Genes Dev. 1998 May 15;12(10):1515-24. doi: 10.1101/gad.12.10.1515. Genes Dev. 1998. PMID: 9585511 Free PMC article.
• Maize contains a Lon protease gene that can partially complement a yeast pim1-deletion mutant.
  Barakat S, Pearce DA, Sherman F, Rapp WD. Barakat S, et al. Plant Mol Biol. 1998 May;37(1):141-54. doi: 10.1023/a:1005912831051. Plant Mol Biol. 1998. PMID: 9620272
• Induction of peroxisomal Lon protease in rat liver after di-(2-ethylhexyl)phthalate treatment.
  Yokota S, Haraguchi CM, Oda T. Yokota S, et al. Histochem Cell Biol. 2008 Jan;129(1):73-83. doi: 10.1007/s00418-007-0328-0. Epub 2007 Oct 11. Histochem Cell Biol. 2008. PMID: 17929048

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Ovid Technologies, Inc.

• Molecular Biology Databases

  • BioCyc
  • Gene Ontology
  • Saccharomyces Genome Database