Programmed cell death and Bcl-2 protection in the absence of a nucleus - PubMed (original) (raw)
Comparative Study
Programmed cell death and Bcl-2 protection in the absence of a nucleus
M D Jacobson et al. EMBO J. 1994.
Abstract
The molecular basis of programmed cell death (PCD) is unknown. An important clue is provided by the Bcl-2 protein, which can protect many cell types from PCD, although it is not known where or how it acts. Nuclear condensation, DNA fragmentation and a requirement for new RNA and protein synthesis are often considered hallmarks of PCD. We show here, however, that anucleate cytoplasts can undergo PCD and that Bcl-2 and extracellular survival signals can protect them, indicating that, in some cases at least, the nucleus is not required for PCD or for Bcl-2 or survival factor protection. We propose that PCD, like the cell cycle, is orchestrated by a cytoplasmic regulator that has multiple intracellular targets.
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References
- Cell. 1993 Nov 19;75(4):641-52 - PubMed
- J Immunol. 1987 Nov 15;139(10):3199-206 - PubMed
- Trends Pharmacol Sci. 1989 Jul;10(7):281-5 - PubMed
- Cell. 1993 Aug 27;74(4):597-608 - PubMed
- Science. 1992 Dec 18;258(5090):1955-7 - PubMed
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