Lipopolysaccharides from Campylobacter jejuni associated with Guillain-Barré syndrome patients mimic human gangliosides in structure - PubMed (original) (raw)

Lipopolysaccharides from Campylobacter jejuni associated with Guillain-Barré syndrome patients mimic human gangliosides in structure

G O Aspinall et al. Infect Immun. 1994 May.

Abstract

Lipopolysaccharides extracted from Campylobacter jejuni serostrains (serotype reference strains) for serotypes O:4 and O:19 were found to have core oligosaccharides with terminal structures resembling human gangliosides GM1 and GD1a. High-molecular-weight molecules that reflected the presence of O chains were shown in immunoblots to be immunologically specific for each serostrain. The O:19 antiserum also reacted strongly with core oligosaccharides of two isolates from patients with Guillain-Barré syndrome (GBS), but the banding patterns and molecular structures were different from those of the O:19 serostrain. A neuraminobiose disaccharide unit is attached to the terminal Gal residue in one isolate, and the other isolate lacked terminal N-acetyl glucosamine and galactose with attached sialic acid so that the sialic acid residues were present in a neuraminobiose unit linked to the only remaining galactose. Analysis of the high-M(r) lipopolysaccharides of the O:19 serostrain and the two isolates from GBS patients revealed the presence of a hyaluronic acid-like polymer with disaccharide-repeating units consisting of beta-D-glucuronic acid amidated with 2-amino-2-deoxyglycerol and N-acetyl glucosamine. The results confirm a potential role for the core oligosaccharides in the etiology of GBS but also suggest that the O-chain polysaccharide may be a contributing factor.

PubMed Disclaimer

Cited by

Post-infectious neurological disorders.
Blackburn KM, Wang C. Blackburn KM, et al. Ther Adv Neurol Disord. 2020 Aug 30;13:1756286420952901. doi: 10.1177/1756286420952901. eCollection 2020. Ther Adv Neurol Disord. 2020. PMID: 32944082 Free PMC article. Review.
Normally occurring human anti-GM1 immunoglobulin M antibodies and the immune response to bacteria.
Alaniz ME, Lardone RD, Yudowski SL, Farace MI, Nores GA. Alaniz ME, et al. Infect Immun. 2004 Apr;72(4):2148-51. doi: 10.1128/IAI.72.4.2148-2151.2004. Infect Immun. 2004. PMID: 15039337 Free PMC article.
Identification of Campylobacter heat-stable and heat-labile antigens by combining the Penner and Lior serotyping schemes.
Woodward DL, Rodgers FG. Woodward DL, et al. J Clin Microbiol. 2002 Mar;40(3):741-5. doi: 10.1128/JCM.40.3.741-745.2002. J Clin Microbiol. 2002. PMID: 11880386 Free PMC article. No abstract available.
The role of infections in autoimmune disease.
Ercolini AM, Miller SD. Ercolini AM, et al. Clin Exp Immunol. 2009 Jan;155(1):1-15. doi: 10.1111/j.1365-2249.2008.03834.x. Clin Exp Immunol. 2009. PMID: 19076824 Free PMC article. Review.
Comparative genomic analysis of Campylobacter jejuni associated with Guillain-Barré and Miller Fisher syndromes: neuropathogenic and enteritis-associated isolates can share high levels of genomic similarity.
Taboada EN, van Belkum A, Yuki N, Acedillo RR, Godschalk PC, Koga M, Endtz HP, Gilbert M, Nash JH. Taboada EN, et al. BMC Genomics. 2007 Oct 5;8:359. doi: 10.1186/1471-2164-8-359. BMC Genomics. 2007. PMID: 17919333 Free PMC article.

References

1. Br Med J (Clin Res Ed). 1982 Jul 17;285(6336):173-4 - PubMed
1. Eur J Clin Microbiol. 1983 Aug;2(4):378-83 - PubMed
1. Br Med J (Clin Res Ed). 1984 Jun 23;288(6434):1867-70 - PubMed
1. Infect Immun. 1987 Aug;55(8):1806-12 - PubMed
1. Pediatr Infect Dis J. 1991 Feb;10(2):149-51 - PubMed

MeSH terms

Substances

LinkOut - more resources

Full Text Sources
Other Literature Sources
- The Lens - Patent Citations Database

Lipopolysaccharides from Campylobacter jejuni associated with Guillain-Barré syndrome patients mimic human gangliosides in structure - PubMed (original) (raw)