Fission yeast gene structure and recognition - PubMed (original) (raw)
Fission yeast gene structure and recognition
M Q Zhang et al. Nucleic Acids Res. 1994.
Free PMC article
Abstract
A database of 210 Schizosaccharomyces pombe DNA sequences (524,794 bp) was extracted from GenBank (release number 81.0) and examined by a number of methods in order to characterize statistical features of these sequences that might serve as signals or constraints for messenger RNA splicing. The statistical information compiled includes splicing signal (donor, acceptor and branch site) profiles, translational initiation start profile, exon/intron length distributions, ORF distribution, CDS size distribution, codon usage table, and 6-tuple distribution. The information content of the various signals are also presented. A rule-based interactive computer program for finding introns called INTRON.PLOT has been developed and was used to successfully analyze 7 newly sequenced genes.
Similar articles
- Architectural features of pre-mRNA introns in the fission yeast Schizosaccharomyces pombe.
Prabhala G, Rosenberg GH, Käufer NF. Prabhala G, et al. Yeast. 1992 Mar;8(3):171-82. doi: 10.1002/yea.320080303. Yeast. 1992. PMID: 1574925 - Pombe: a gene-finding and exon-intron structure prediction system for fission yeast.
Chen T, Zhang MQ. Chen T, et al. Yeast. 1998 Jun 15;14(8):701-10. doi: 10.1002/(SICI)1097-0061(19980615)14:8<701::AID-YEA247>3.0.CO;2-#. Yeast. 1998. PMID: 9675815 - Introduction of functional artificial introns into the naturally intronless ura4 gene of Schizosaccharomyces pombe.
Gatermann KB, Hoffmann A, Rosenberg GH, Käufer NF. Gatermann KB, et al. Mol Cell Biol. 1989 Apr;9(4):1526-35. doi: 10.1128/mcb.9.4.1526-1535.1989. Mol Cell Biol. 1989. PMID: 2725514 Free PMC article. - Pre-mRNA splicing in Schizosaccharomyces pombe: regulatory role of a kinase conserved from fission yeast to mammals.
Kuhn AN, Käufer NF. Kuhn AN, et al. Curr Genet. 2003 Feb;42(5):241-51. doi: 10.1007/s00294-002-0355-2. Epub 2002 Dec 13. Curr Genet. 2003. PMID: 12589463 Review. - Introns as mobile genetic elements.
Lambowitz AM, Belfort M. Lambowitz AM, et al. Annu Rev Biochem. 1993;62:587-622. doi: 10.1146/annurev.bi.62.070193.003103. Annu Rev Biochem. 1993. PMID: 8352597 Review. No abstract available.
Cited by
- Peculiarities of Yeasts and Human Telomerase RNAs Processing.
Rubtsova MP, Vasilkova DP, Naraykina YV, Dontsova OA. Rubtsova MP, et al. Acta Naturae. 2016 Oct-Dec;8(4):14-22. Acta Naturae. 2016. PMID: 28050263 Free PMC article. - Intronic sequence elements impede exon ligation and trigger a discard pathway that yields functional telomerase RNA in fission yeast.
Kannan R, Hartnett S, Voelker RB, Berglund JA, Staley JP, Baumann P. Kannan R, et al. Genes Dev. 2013 Mar 15;27(6):627-38. doi: 10.1101/gad.212738.112. Epub 2013 Mar 6. Genes Dev. 2013. PMID: 23468430 Free PMC article. - Large-scale comparative analysis of splicing signals and their corresponding splicing factors in eukaryotes.
Schwartz SH, Silva J, Burstein D, Pupko T, Eyras E, Ast G. Schwartz SH, et al. Genome Res. 2008 Jan;18(1):88-103. doi: 10.1101/gr.6818908. Epub 2007 Nov 21. Genome Res. 2008. PMID: 18032728 Free PMC article. - Analysis of mutant phenotypes and splicing defects demonstrates functional collaboration between the large and small subunits of the essential splicing factor U2AF in vivo.
Webb CJ, Lakhe-Reddy S, Romfo CM, Wise JA. Webb CJ, et al. Mol Biol Cell. 2005 Feb;16(2):584-96. doi: 10.1091/mbc.e04-09-0768. Epub 2004 Nov 17. Mol Biol Cell. 2005. PMID: 15548596 Free PMC article. - Introns and splicing elements of five diverse fungi.
Kupfer DM, Drabenstot SD, Buchanan KL, Lai H, Zhu H, Dyer DW, Roe BA, Murphy JW. Kupfer DM, et al. Eukaryot Cell. 2004 Oct;3(5):1088-100. doi: 10.1128/EC.3.5.1088-1100.2004. Eukaryot Cell. 2004. PMID: 15470237 Free PMC article.
References
- Proc Natl Acad Sci U S A. 1977 Aug;74(8):3171-5 - PubMed
- Methods Enzymol. 1990;183:211-21 - PubMed
- Nucleic Acids Res. 1982 Jan 22;10(2):459-72 - PubMed
- Cell. 1983 Jun;33(2):509-18 - PubMed
- Nucleic Acids Res. 1984 Nov 26;12(22):8295-312 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources