Dynamic instability of microtubules as an efficient way to search in space - PubMed (original) (raw)
Dynamic instability of microtubules as an efficient way to search in space
T E Holy et al. Proc Natl Acad Sci U S A. 1994.
Abstract
During the formation of the mitotic spindle, dynamic microtubules search for chromosomes in the surrounding cytosol. The average time required to reach such "targets" is calculated within a simple model of dynamic instability. The values of the dynamic parameters that minimize this search time are also obtained. The results approximate well observations of the capture of chromosomes in prometaphase cells. Compared to usual reversible polymerization, dynamic instability reduces the time required to find a target by several orders of magnitude.
Similar articles
- Dynamic microtubules are essential for efficient chromosome capture and biorientation in S. cerevisiae.
Huang B, Huffaker TC. Huang B, et al. J Cell Biol. 2006 Oct 9;175(1):17-23. doi: 10.1083/jcb.200606021. J Cell Biol. 2006. PMID: 17030980 Free PMC article. - Efficient chromosome capture requires a bias in the 'search-and-capture' process during mitotic-spindle assembly.
Wollman R, Cytrynbaum EN, Jones JT, Meyer T, Scholey JM, Mogilner A. Wollman R, et al. Curr Biol. 2005 May 10;15(9):828-32. doi: 10.1016/j.cub.2005.03.019. Curr Biol. 2005. PMID: 15886100 - Chromosome capture: take me to your kinetochore.
Odde DJ. Odde DJ. Curr Biol. 2005 May 10;15(9):R328-30. doi: 10.1016/j.cub.2005.04.027. Curr Biol. 2005. PMID: 15886087 Review. - Beyond self-assembly: from microtubules to morphogenesis.
Kirschner M, Mitchison T. Kirschner M, et al. Cell. 1986 May 9;45(3):329-42. doi: 10.1016/0092-8674(86)90318-1. Cell. 1986. PMID: 3516413 Review. No abstract available. - Diffusion and formation of microtubule asters: physical processes versus biochemical regulation.
Dogterom M, Maggs AC, Leibler S. Dogterom M, et al. Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):6683-8. doi: 10.1073/pnas.92.15.6683. Proc Natl Acad Sci U S A. 1995. PMID: 7624308 Free PMC article.
Cited by
- The Hill function is the universal Hopfield barrier for sharpness of input-output responses.
Martinez-Corral R, Nam KM, DePace AH, Gunawardena J. Martinez-Corral R, et al. Proc Natl Acad Sci U S A. 2024 May 28;121(22):e2318329121. doi: 10.1073/pnas.2318329121. Epub 2024 May 24. Proc Natl Acad Sci U S A. 2024. PMID: 38787881 Free PMC article. - On the critical concentration for net assembly of dynamically unstable polymers.
Mullins RD. Mullins RD. bioRxiv [Preprint]. 2024 Apr 13:2024.04.12.589322. doi: 10.1101/2024.04.12.589322. bioRxiv. 2024. PMID: 38645192 Free PMC article. Preprint. - The Hill function is the universal Hopfield barrier for sharpness of input-output responses.
Martinez-Corral R, Nam KM, DePace AH, Gunawardena J. Martinez-Corral R, et al. bioRxiv [Preprint]. 2024 Mar 28:2024.03.27.587054. doi: 10.1101/2024.03.27.587054. bioRxiv. 2024. PMID: 38585761 Free PMC article. Updated. Preprint. - Pattern recognition in the nucleation kinetics of non-equilibrium self-assembly.
Evans CG, O'Brien J, Winfree E, Murugan A. Evans CG, et al. Nature. 2024 Jan;625(7995):500-507. doi: 10.1038/s41586-023-06890-z. Epub 2024 Jan 17. Nature. 2024. PMID: 38233621 Free PMC article. - Emergent programmable behavior and chaos in dynamically driven active filaments.
Krishnamurthy D, Prakash M. Krishnamurthy D, et al. Proc Natl Acad Sci U S A. 2023 Jul 11;120(28):e2304981120. doi: 10.1073/pnas.2304981120. Epub 2023 Jul 5. Proc Natl Acad Sci U S A. 2023. PMID: 37406100 Free PMC article.
References
- J Cell Biol. 1992 Sep;118(5):1097-108 - PubMed
- J Biol Chem. 1992 Apr 25;267(12):7995-8006 - PubMed
- Chromosoma. 1976 Mar 10;54(4):363-85 - PubMed
- Cell. 1979 Jun;17(2):319-25 - PubMed
- Cell. 1981 Aug;25(2):537-46 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources