Determinants of anisotropic water diffusion in nerves - PubMed (original) (raw)
Determinants of anisotropic water diffusion in nerves
C Beaulieu et al. Magn Reson Med. 1994 Apr.
Abstract
We report NMR diffusion measurements of water in three central nervous system models, namely the nonmyelinated olfactory, and the myelinated trigeminal and optic nerves of the spotted and long-nosed garfish. A similar degree of anisotropy of the average diffusion coefficients (DNMR) is observed for all three freshly excised nerve types (DNMR(parallel)/DNMR-(perpendicular) is 3.6 +/- 1.2, 3.2 +/- 0.9, and 2.6 +/- 0.4 for the olfactory, trigeminal, and optic nerves, respectively). The anisotropy of DNMR for the nonmyelinated olfactory nerve argues strongly that myelin is not a necessary determinant of diffusional anisotropy in ordered axonal systems (even though it may contribute when present). Garfish nerves treated with vinblastine, in order to depolymerize microtubules and inhibit fast axonal transport, also exhibit diffusional anisotropy (DNMR(parallel)/DNMR(perpendicular) is 2.6 +/- 0.4, 2.8 +/- 0.8, and 2.2 +/- 0.7 for the olfactory, trigeminal, and optic nerves, respectively) thus excluding a significant role for microtubules and fast axonal transport in that observed anisotropy.
Similar articles
- Multicomponent water proton transverse relaxation and T2-discriminated water diffusion in myelinated and nonmyelinated nerve.
Beaulieu C, Fenrich FR, Allen PS. Beaulieu C, et al. Magn Reson Imaging. 1998 Dec;16(10):1201-10. doi: 10.1016/s0730-725x(98)00151-9. Magn Reson Imaging. 1998. PMID: 9858277 - An in vitro evaluation of the effects of local magnetic-susceptibility-induced gradients on anisotropic water diffusion in nerve.
Beaulieu C, Allen PS. Beaulieu C, et al. Magn Reson Med. 1996 Jul;36(1):39-44. doi: 10.1002/mrm.1910360108. Magn Reson Med. 1996. PMID: 8795018 - Axonal transport in the garfish optic nerve: comparison with the olfactory system.
Cancalon PF. Cancalon PF. J Neurochem. 1988 Jul;51(1):266-76. doi: 10.1111/j.1471-4159.1988.tb04866.x. J Neurochem. 1988. PMID: 2454295 - Physical characterization using diffusion NMR spectroscopy.
Zubkov M, Dennis GR, Stait-Gardner T, Torres AM, Willis SA, Zheng G, Price WS. Zubkov M, et al. Magn Reson Chem. 2017 May;55(5):414-424. doi: 10.1002/mrc.4530. Epub 2016 Oct 17. Magn Reson Chem. 2017. PMID: 27657736 Review. - [Structural anatomy of cranial nerves (V, VII, VIII, IX, X)].
Guclu B, Meyronet D, Simon E, Streichenberger N, Sindou M, Mertens P. Guclu B, et al. Neurochirurgie. 2009 Apr;55(2):92-8. doi: 10.1016/j.neuchi.2009.02.001. Epub 2009 Mar 27. Neurochirurgie. 2009. PMID: 19328501 Review. French.
Cited by
- Neuroimaging modalities in the detection of Alzheimer's disease-associated biomarkers.
Dang C, Wang Y, Li Q, Lu Y. Dang C, et al. Psychoradiology. 2023 Jun 22;3:kkad009. doi: 10.1093/psyrad/kkad009. eCollection 2023. Psychoradiology. 2023. PMID: 38666112 Free PMC article. Review. - Insights and improvements in correspondence between axonal volume fraction measured with diffusion-weighted MRI and electron microscopy.
Papazoglou S, Ashtarayeh M, Oeschger JM, Callaghan MF, Does MD, Mohammadi S. Papazoglou S, et al. NMR Biomed. 2024 Mar;37(3):e5070. doi: 10.1002/nbm.5070. Epub 2023 Dec 14. NMR Biomed. 2024. PMID: 38098204 Free PMC article. - Sensation seeking correlates with increased white matter integrity of structures associated with visuospatial processing in healthy adults.
Escelsior A, Inuggi A, Amadeo MB, Engel-Yeger B, Trabucco A, Esposito D, Campus C, Bovio A, Comparini S, Pereira da Silva B, Serafini G, Gori M, Amore M. Escelsior A, et al. Front Neurosci. 2023 Oct 26;17:1267700. doi: 10.3389/fnins.2023.1267700. eCollection 2023. Front Neurosci. 2023. PMID: 37954876 Free PMC article. - Contributions to auditory system conduction velocity: insights with multi-modal neuroimaging and machine learning in children with ASD and XYY syndrome.
Berman JI, Bloy L, Blaskey L, Jackel CR, Miller JS, Ross J, Edgar JC, Roberts TPL. Berman JI, et al. Front Psychiatry. 2023 May 11;14:1057221. doi: 10.3389/fpsyt.2023.1057221. eCollection 2023. Front Psychiatry. 2023. PMID: 37252131 Free PMC article. - Utility of MRI in Quantifying Tissue Injury in Cervical Spondylotic Myelopathy.
Khan AF, Haynes G, Mohammadi E, Muhammad F, Hameed S, Smith ZA. Khan AF, et al. J Clin Med. 2023 May 8;12(9):3337. doi: 10.3390/jcm12093337. J Clin Med. 2023. PMID: 37176777 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources