A yeast protein similar to bacterial two-component regulators - PubMed (original) (raw)

. 1993 Oct 22;262(5133):566-9.

doi: 10.1126/science.8211183.

Affiliations

A yeast protein similar to bacterial two-component regulators

I M Ota et al. Science. 1993.

Abstract

Many bacterial signaling pathways involve a two-component design. In these pathways, a sensor kinase, when activated by a signal, phosphorylates its own histidine, which then serves as a phosphoryl donor to an aspartate in a response regulator protein. The Sln1 protein of the yeast Saccharomyces cerevisiae has sequence similarities to both the histidine kinase and the response regulator proteins of bacteria. A missense mutation in SLN1 is lethal in the absence but not in the presence of the N-end rule pathway, a ubiquitin-dependent proteolytic system. The finding of SLN1 demonstrates that a mode of signal transduction similar to the bacterial two-component design operates in eukaryotes as well.

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