Compositional changes of AP-1 DNA-binding proteins are regulated by light in a mammalian circadian clock - PubMed (original) (raw)
Compositional changes of AP-1 DNA-binding proteins are regulated by light in a mammalian circadian clock
J Takeuchi et al. Neuron. 1993 Nov.
Abstract
Recent reports have shown that the nuclear phosphoprotein Fos is induced by light in a mammalian circadian clock, the suprachiasmatic nucleus. To learn how light and circadian phase affect the binding of Fos to DNA, we analyzed the photic and temporal regulation of immunoreactive Jun protein expression and AP-1 DNA-binding activity in the rat suprachiasmatic nucleus. Immunohistochemistry and gel mobility shift assays suggest that AP-1 activity during the night and after a light pulse consists of constant, as well as variable, protein components; JunD could be identified as a constituent of both dark- and light-activated binding complexes, whereas binding by JunB and Fos could be implicated only after photic stimulation. Since JunD or JunB could be colocalized with Fos in individual suprachiasmatic nucleus cell nuclei, light may be acting in at least some suprachiasmatic nucleus cells by altering AP-1 protein composition rather than binding site occupancy.
Similar articles
- Light-induced variations in AP-1 binding activity and composition in the rat suprachiasmatic nucleus.
François-Bellan AM, Deprez P, Becquet D. François-Bellan AM, et al. J Neurochem. 1999 Feb;72(2):841-7. doi: 10.1046/j.1471-4159.1999.0720841.x. J Neurochem. 1999. PMID: 9930761 - Circadian binding activity of AP-1, a regulator of the arylalkylamine N-acetyltransferase gene in the rat pineal gland, depends on circadian Fra-2, c-Jun, and Jun-D expression and is regulated by the clock's zeitgebers.
Guillaumond F, Sage D, Deprez P, Bosler O, Becquet D, François-Bellan AM. Guillaumond F, et al. J Neurochem. 2000 Oct;75(4):1398-407. doi: 10.1046/j.1471-4159.2000.0751398.x. J Neurochem. 2000. PMID: 10987819 - Differential regulation of fos family genes in the ventrolateral and dorsomedial subdivisions of the rat suprachiasmatic nucleus.
Schwartz WJ, Carpino A Jr, de la Iglesia HO, Baler R, Klein DC, Nakabeppu Y, Aronin N. Schwartz WJ, et al. Neuroscience. 2000;98(3):535-47. doi: 10.1016/s0306-4522(00)00140-8. Neuroscience. 2000. PMID: 10869847 - Hamsters running on time: is the lateral habenula a part of the clock?
Tavakoli-Nezhad M, Schwartz WJ. Tavakoli-Nezhad M, et al. Chronobiol Int. 2006;23(1-2):217-24. doi: 10.1080/07420520500521947. Chronobiol Int. 2006. PMID: 16687295 Review.
Cited by
- Rapid resetting of the mammalian circadian clock.
Best JD, Maywood ES, Smith KL, Hastings MH. Best JD, et al. J Neurosci. 1999 Jan 15;19(2):828-35. doi: 10.1523/JNEUROSCI.19-02-00828.1999. J Neurosci. 1999. PMID: 9880602 Free PMC article. - Circadian variation in rat brain AP-1 DNA binding activity after cholinergic stimulation: modulation by lithium.
Williams MB, Jope RS. Williams MB, et al. Psychopharmacology (Berl). 1995 Dec;122(4):363-8. doi: 10.1007/BF02246267. Psychopharmacology (Berl). 1995. PMID: 8657834 - The mouse Clock locus: sequence and comparative analysis of 204 kb from mouse chromosome 5.
Wilsbacher LD, Sangoram AM, Antoch MP, Takahashi JS. Wilsbacher LD, et al. Genome Res. 2000 Dec;10(12):1928-40. doi: 10.1101/gr.10.12.1928. Genome Res. 2000. PMID: 11116088 Free PMC article. - Light, immediate-early genes, and circadian rhythms.
Kornhauser JM, Mayo KE, Takahashi JS. Kornhauser JM, et al. Behav Genet. 1996 May;26(3):221-40. doi: 10.1007/BF02359382. Behav Genet. 1996. PMID: 8754249 Review. - The circadian clock in cancer development and therapy.
Fu L, Kettner NM. Fu L, et al. Prog Mol Biol Transl Sci. 2013;119:221-82. doi: 10.1016/B978-0-12-396971-2.00009-9. Prog Mol Biol Transl Sci. 2013. PMID: 23899600 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous