Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members - PubMed (original) (raw)
. 1993 Dec 3;262(5139):1557-60.
doi: 10.1126/science.8248803.
Affiliations
- PMID: 8248803
- DOI: 10.1126/science.8248803
Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members
W Krek et al. Science. 1993.
Abstract
The E2F family of transcription factors functions in the control of the mammalian cell cycle. Here it is shown that two family members, E2F-1 and DP-1, form specific heterodimers in vivo, a process that enhances DNA binding, transactivation, and the binding of the retinoblastoma gene product. These results suggest that heterodimerization regulates E2F function and contributes to cell cycle control.
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