Restriction and enhancement of human immunodeficiency virus type 1 replication by modulation of intracellular deoxynucleoside triphosphate pools - PubMed (original) (raw)

Comparative Study

Restriction and enhancement of human immunodeficiency virus type 1 replication by modulation of intracellular deoxynucleoside triphosphate pools

A Meyerhans et al. J Virol. 1994 Jan.

Abstract

Human immunodeficiency virus type 1 (HIV-1) replication is shown to be sensitive to the intracellular concentration of deoxynucleoside triphosphate substrates. Addition of thymidine to established cell lines resulted in a dramatic reduction of virus production. The effect could be substantially alleviated by addition of deoxycytidine, which, alone, enhanced viral titers by a factor of 2 to 3. Hydroxyurea treatment abolished HIV-1 replication in peripheral blood mononuclear cells and could be reversed by deoxyadenosine. These data show that HIV-1 replication occurs under suboptimal DNA precursor conditions.

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References

1. 1. Virology. 1991 Dec;185(2):661-72 - PubMed
2. 1. Mol Gen Genet. 1991 Apr;226(1-2):257-64 - PubMed
3. 1. J Biol Chem. 1992 Feb 25;267(6):3589-96 - PubMed
4. 1. Infect Immun. 1992 Mar;60(3):742-8 - PubMed
5. 1. Biochem Pharmacol. 1982 Oct 1;31(19):3107-13 - PubMed

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