Biogenesis of constitutive secretory vesicles, secretory granules and synaptic vesicles - PubMed (original) (raw)

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Biogenesis of constitutive secretory vesicles, secretory granules and synaptic vesicles

R Bauerfeind et al. Curr Opin Cell Biol. 1993 Aug.

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Abstract

The formation of constitutive secretory vesicles and secretory granules from the trans-Golgi network is inhibited by brefeldin A, suggesting a role for ADP ribosylation factor and other coat proteins in the budding process, and is regulated by multiple heterotrimeric G proteins. Membrane proteins are sorted to secretory granules through signals in their cytoplasmic domains and, like secretory proteins, by aggregation of their lumenal domains. Synaptic vesicle membrane proteins undergo exocytotic-endocytotic recycling before synapse formation, consistent with the proposed biogenesis of synaptic vesicles from early endosomes.

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