Distinct DNA binding preferences for the c-Myc/Max and Max/Max dimers - PubMed (original) (raw)
Distinct DNA binding preferences for the c-Myc/Max and Max/Max dimers
D L Solomon et al. Nucleic Acids Res. 1993.
Free PMC article
Abstract
The transcription factor c-Myc and its dimerisation partner Max are members of the basic/helix-loop-helix/leucine-zipper (bHLH-Z) family and bind to the DNA core sequence CACGTG. Using a site-selection protocol, we determined the complete 12 base pair consensus binding sites of c-Myc/Max (RACCACGTGGTY) and Max/Max (RANCACGTGNTY) dimers. We find that the c-Myc/Max dimer fails to bind the core when it is flanked by a 5'T or a 3'A, while the Max/Max dimer readily binds such sequences. Furthermore we show that inappropriate flanking sequences preclude transactivation by c-Myc in vivo. In conclusion, Max/Max dimers are less discriminatory than c-Myc/Max and may regulate other genes in addition to c-Myc/Max targets.
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References
- Science. 1990 Nov 23;250(4984):1104-10 - PubMed
- Curr Opin Cell Biol. 1992 Jun;4(3):468-74 - PubMed
- Mol Cell Biol. 1987 May;7(5):1697-709 - PubMed
- Nucleic Acids Res. 1987 Jul 10;15(13):5490 - PubMed
- Gene. 1988 Jul 30;67(2):271-7 - PubMed
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