Synaptic inhibition regulates associative interactions between afferents during the induction of long-term potentiation and depression - PubMed (original) (raw)

Synaptic inhibition regulates associative interactions between afferents during the induction of long-term potentiation and depression

R A Tomasulo et al. Proc Natl Acad Sci U S A. 1993.

Abstract

The induction of long-term potentiation and depression depends upon associative interactions between synapses that converge on individual dendrites. The distance over which these associative interactions occur is limited. The present study evaluates whether this limitation is regulated by synaptic inhibition. We evaluated the associative interactions between two inputs that terminate on different proximo-distal locations along the dendrites of dentate granule cells in the presence of the gamma-aminobutyric acid (GABA) antagonist bicuculline methiodide. Local blockade of GABAergic inhibition enhanced associative interactions between nonoverlapping inputs, compared to within-animal control sites, where inhibitory transmission was intact. The results suggest that synaptic inhibition limits interactions between excitatory synapses by creating current shunts that limit the spread of depolarization within the dendritic tree.

PubMed Disclaimer

Cited by

Phrenic motoneuron structural plasticity across models of diaphragm muscle paralysis.
Mantilla CB, Zhan WZ, Gransee HM, Prakash YS, Sieck GC. Mantilla CB, et al. J Comp Neurol. 2018 Dec 15;526(18):2973-2983. doi: 10.1002/cne.24503. Epub 2018 Nov 8. J Comp Neurol. 2018. PMID: 30411341 Free PMC article.
Multiple shared mechanisms for homeostatic plasticity in rodent somatosensory and visual cortex.
Gainey MA, Feldman DE. Gainey MA, et al. Philos Trans R Soc Lond B Biol Sci. 2017 Mar 5;372(1715):20160157. doi: 10.1098/rstb.2016.0157. Philos Trans R Soc Lond B Biol Sci. 2017. PMID: 28093551 Free PMC article. Review.
Endogenous activation of mu and delta-1 opioid receptors is required for long-term potentiation induction in the lateral perforant path: dependence on GABAergic inhibition.
Bramham CR, Sarvey JM. Bramham CR, et al. J Neurosci. 1996 Dec 15;16(24):8123-31. doi: 10.1523/JNEUROSCI.16-24-08123.1996. J Neurosci. 1996. PMID: 8987837 Free PMC article.
Cooperative interactions in the induction of long-term potentiation and depression of synaptic excitation between hippocampal CA3-CA1 cell pairs in vitro.
Debanne D, Gähwiler BH, Thompson SM. Debanne D, et al. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):11225-30. doi: 10.1073/pnas.93.20.11225. Proc Natl Acad Sci U S A. 1996. PMID: 8855337 Free PMC article.
Cooperative interactions among afferents govern the induction of homosynaptic long-term depression in the hippocampus.
Kerr DS, Abraham WC. Kerr DS, et al. Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11637-41. doi: 10.1073/pnas.92.25.11637. Proc Natl Acad Sci U S A. 1995. PMID: 8524819 Free PMC article.

References

1. Brain Res. 1979 Oct 19;175(2):233-45 - PubMed
1. Brain Res. 1993 Jun 11;613(2):309-12 - PubMed
1. Brain Res. 1984 Feb 20;293(2):353-9 - PubMed
1. Acta Physiol Scand. 1985 Sep;125(1):159-72 - PubMed
1. Acta Physiol Scand. 1986 Feb;126(2):317-9 - PubMed

Synaptic inhibition regulates associative interactions between afferents during the induction of long-term potentiation and depression - PubMed (original) (raw)