Linkage disequilibrium in the white locus region of Drosophila melanogaster - PubMed (original) (raw)

Linkage disequilibrium in the white locus region of Drosophila melanogaster

N T Miyashita et al. Genet Res. 1993 Oct.

Abstract

Linkage disequilibrium between molecular polymorphisms in a 10 kb region in the white locus of Drosophila melanogaster, revealed with a battery of four-cutter restriction enzymes, was investigated in 266 lines sampled from seven natural populations around the world. A total of 73 (35 restriction site, 37 insertion/deletion and 1 inversion) polymorphisms were detected, of which 55 non-unique polymorphisms were analysed for linkage disequilibrium. Clustering of significant linkage disequilibrium was observed in the transcriptional unit of the white locus as in Miyashita & Langley (1988). It was shown that about two thirds of the 2-locus combinations showing significant linkage disequilibrium have similar degree and direction of association over different populations. Despite lower divergence in allelic frequencies of molecular polymorphisms among populations, an increase in the proportion of 2-locus pairs showing significant linkage disequilibrium is observed in the transcriptional unit. Large values of Ohta's D measure ratio (1982a, b) cluster in the transcriptional unit, and correspond to significant linkage disequilibria. Although the exact molecular mechanism is not clear, these results suggest that epistatic selection is responsible for significant linkage disequilibrium in the transcriptional unit of this locus.

PubMed Disclaimer

Similar articles

• Molecular and phenotypic variation of the white locus region in Drosophila melanogaster.
  Miyashita N, Langley CH. Miyashita N, et al. Genetics. 1988 Sep;120(1):199-212. doi: 10.1093/genetics/120.1.199. Genetics. 1988. PMID: 2906026 Free PMC article.
• Restriction-map variation in natural populations of Drosophila melanogaster: white-locus region.
  Langley CH, Aquadro CF. Langley CH, et al. Mol Biol Evol. 1987 Nov;4(6):651-63. doi: 10.1093/oxfordjournals.molbev.a040467. Mol Biol Evol. 1987. PMID: 2895415
• Patterns of naturally occurring restriction map variation, dopa decarboxylase activity variation and linkage disequilibrium in the Ddc gene region of Drosophila melanogaster.
  Aquadro CF, Jennings RM Jr, Bland MM, Laurie CC, Langley CH. Aquadro CF, et al. Genetics. 1992 Oct;132(2):443-52. doi: 10.1093/genetics/132.2.443. Genetics. 1992. PMID: 1358752 Free PMC article.
• Restriction endonuclease map variation in the Adh region in populations of Drosophila melanogaster.
  Cross SR, Birley AJ. Cross SR, et al. Biochem Genet. 1986 Jun;24(5-6):415-33. doi: 10.1007/BF00499097. Biochem Genet. 1986. PMID: 3017296
• Confounding by linkage disequilibrium.
  Aissani B. Aissani B. J Hum Genet. 2014 Feb;59(2):110-5. doi: 10.1038/jhg.2013.130. Epub 2013 Dec 19. J Hum Genet. 2014. PMID: 24352001 Free PMC article. Review. No abstract available.

Cited by

• Using the variability of linkage disequilibrium between subpopulations to infer sweeps and epistatic selection in a diverse panel of chickens.
  Beissinger TM, Gholami M, Erbe M, Weigend S, Weigend A, de Leon N, Gianola D, Simianer H. Beissinger TM, et al. Heredity (Edinb). 2016 Feb;116(2):158-66. doi: 10.1038/hdy.2015.81. Epub 2015 Sep 9. Heredity (Edinb). 2016. PMID: 26350629 Free PMC article.
• An amino acid polymorphism in the couch potato gene forms the basis for climatic adaptation in Drosophila melanogaster.
  Schmidt PS, Zhu CT, Das J, Batavia M, Yang L, Eanes WF. Schmidt PS, et al. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16207-11. doi: 10.1073/pnas.0805485105. Epub 2008 Oct 13. Proc Natl Acad Sci U S A. 2008. PMID: 18852464 Free PMC article.
• The effect of polymorphisms in the enhancer of split gene complex on bristle number variation in a large wild-caught cohort of Drosophila melanogaster.
  Macdonald SJ, Pastinen T, Long AD. Macdonald SJ, et al. Genetics. 2005 Dec;171(4):1741-56. doi: 10.1534/genetics.105.045344. Epub 2005 Sep 2. Genetics. 2005. PMID: 16143618 Free PMC article.
• DNA sequence polymorphism and divergence at the erect wing and suppressor of sable loci of Drosophila melanogaster and D. simulans.
  Braverman JM, Lazzaro BP, Aguadé M, Langley CH. Braverman JM, et al. Genetics. 2005 Jul;170(3):1153-65. doi: 10.1534/genetics.104.033456. Epub 2005 Jun 8. Genetics. 2005. PMID: 15944367 Free PMC article.
• Nucleotide variation in the tinman and bagpipe homeobox genes of Drosophila melanogaster.
  Balakirev ES, Ayala FJ. Balakirev ES, et al. Genetics. 2004 Apr;166(4):1845-56. doi: 10.1534/genetics.166.4.1845. Genetics. 2004. PMID: 15126403 Free PMC article.

MeSH terms

LinkOut - more resources

• Molecular Biology Databases

  • FlyBase