[The immunogenic properties of a recombinant vaccinia virus with an incorporated DNA copy of the 26S RNA of the Venezuelan equine encephalomyelitis virus] - PubMed (original) (raw)
. 1993 Sep-Dec;38(5):222-6.
[Article in Russian]
- PMID: 8284922
[The immunogenic properties of a recombinant vaccinia virus with an incorporated DNA copy of the 26S RNA of the Venezuelan equine encephalomyelitis virus]
[Article in Russian]
V A Sviatchenko et al. Vopr Virusol. 1993 Sep-Dec.
Abstract
A recombinant strain of vaccinia virus (VR26) containing a DNA-copy of the subgenomic 26S RNA of Venezuelan equine encephalomyelitis virus (VEE) inserted into the coding region of thymidine kinase (TK) gene was produced. This subgenomic RNA contained the genes for all structural proteins of the VEE virus, the strain Trinidad donkey (TRD). VR26 effectively expressed VEE virus glycoproteins on the membranes of the infected cells. Blood sera of VR26-immunized animals were found to contain VEE virus-specific antibodies. VR26-immunized mice and rabbits showed a high level of resistance to subcutaneous inoculation with the pathogenic TRD strain of VEE virus. VR26 also provided a high level of protection in animals against aerogenic infection. The absence of virus-neutralizing antibodies in most VR26-immunized animals resistant to inoculation with high doses of VEE suggests the dominant role of the cell component in the immune response. The immune response induced by the recombinant VR26 strain was stable as demonstrated by the resistance of the animals to a challenge with VEE virus 7 months after immunization. The experimental results suggest that this recombinant strain may be considered as a candidate for vaccine preparation.
Similar articles
- [Immunogenicity of a recombinant strain of vaccinia virus, expressing a Venezuelan equine encephalomyelitis virus structural protein gene in peroral immunization].
Sviatchenko VA, Kiselev NN, Ryzhikov AB, Bulychev LE, Mikriukova TP, Netesov SV. Sviatchenko VA, et al. Vopr Virusol. 2000 Nov-Dec;45(6):38-41. Vopr Virusol. 2000. PMID: 11200645 Russian. - Improved protection against Venezuelan equine encephalitis by genetic engineering of a recombinant vaccinia virus.
Bennett AM, Lescott T, Phillpotts RJ. Bennett AM, et al. Viral Immunol. 1998;11(3):109-17. doi: 10.1089/vim.1998.11.109. Viral Immunol. 1998. PMID: 9918402 - Recombinant vaccinia virus/Venezuelan equine encephalitis (VEE) virus protects mice from peripheral VEE virus challenge.
Kinney RM, Esposito JJ, Mathews JH, Johnson BJ, Roehrig JT, Barrett AD, Trent DW. Kinney RM, et al. J Virol. 1988 Dec;62(12):4697-702. doi: 10.1128/JVI.62.12.4697-4702.1988. J Virol. 1988. PMID: 3184276 Free PMC article. - Melatonin and viral infections.
Bonilla E, Valero N, Chacín-Bonilla L, Medina-Leendertz S. Bonilla E, et al. J Pineal Res. 2004 Mar;36(2):73-9. doi: 10.1046/j.1600-079x.2003.00105.x. J Pineal Res. 2004. PMID: 14962057 Free PMC article. Review. - Expression of cytokines by recombinant vaccinia viruses: a model for studying cytokines in virus infections in vivo.
Ramshaw I, Ruby J, Ramsay A, Ada G, Karupiah G. Ramshaw I, et al. Immunol Rev. 1992 Jun;127:157-82. doi: 10.1111/j.1600-065x.1992.tb01413.x. Immunol Rev. 1992. PMID: 1354650 Review. No abstract available.
Cited by
- A novel MVA vectored Chikungunya virus vaccine elicits protective immunity in mice.
Weger-Lucarelli J, Chu H, Aliota MT, Partidos CD, Osorio JE. Weger-Lucarelli J, et al. PLoS Negl Trop Dis. 2014 Jul 24;8(7):e2970. doi: 10.1371/journal.pntd.0002970. eCollection 2014 Jul. PLoS Negl Trop Dis. 2014. PMID: 25058320 Free PMC article. - Design of chimeric alphaviruses with a programmed, attenuated, cell type-restricted phenotype.
Kim DY, Atasheva S, Foy NJ, Wang E, Frolova EI, Weaver S, Frolov I. Kim DY, et al. J Virol. 2011 May;85(9):4363-76. doi: 10.1128/JVI.00065-11. Epub 2011 Feb 23. J Virol. 2011. PMID: 21345954 Free PMC article. - Comparative analysis of the alphavirus-based vectors expressing Rift Valley fever virus glycoproteins.
Gorchakov R, Volkova E, Yun N, Petrakova O, Linde NS, Paessler S, Frolova E, Frolov I. Gorchakov R, et al. Virology. 2007 Sep 15;366(1):212-25. doi: 10.1016/j.virol.2007.04.014. Epub 2007 May 16. Virology. 2007. PMID: 17507072 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources